Multifunctional Hybrid Microfibers of h-BN/MoS₂ Pullulan Produced by Force-Spinning Method With Potential Use in Biomedical Applications

Pullulan-based microfibers containing 0.25 wt% of h-BN, MoS₂, and their hybrid (h-BN/MoS₂) were successfully produced by the Centrifugal Force Spinning Method (CFSM) and characterized by TGA, SEM, XRD, XPS, DSC and tensile tests. The nanofiller-loaded fibers exhibited thermal behavior comparable to neat pullulan, with similar T_g and stability. Tensile stress–strain tests showed up to ~45% and ~30% increases in ultimate tensile strength and modulus, respectively, while maintaining elongation. The hybrid h-BN/MoS₂ system achieved the most balanced reinforcement, evidencing a synergistic effect. Moreover, the microfibers preserved high HaCaT cell viability and inhibited Escherichia coli and Staphylococcus aureus growth by up to 67%, highlighting their multifunctional potential for biomedical and technological applications. This approach imparted the multifunctional character to these microfibers, with balanced thermal, mechanical, and biological properties, enabling their potential use in various technological fields.