Neuroanatomical interpretation of the main motor symptoms and non-motor symptoms in Parkinson's disease

Parkinson's disease is one of the most complex and interesting affections of the central nervous system. Since its description in 1817 by James Parkinson, the cause of the malady is still a mystery, but research in this field is intense and constant scientific breakthroughs help to clarify the perspective. Nowadays there is no curative treatment available for the disease and we only count with palliative therapies to alleviate symptoms, therefore it is necessary to understand profoundly the nervous structures involved in its genesis, that way we will be able to find a cure for the malady. In this article we present an actualized review of the main affected neuroanatomic pathways and their clinical translation into motor and non-motor symptoms.