Dietary interventions in patients with obesity and their impact on Akkermansia muciniphila abundance: A systematic review.

The anaerobic bacteria Akkermansia muciniphila has shown since its discovery its role for
metabolism and inflammation markers regulation. A systematic review was made to analyze dietary
clinical interventions that reflect the association between obese phenotype or state and A. muciniphila
concentration in gut microbiota, after specific nutritional modifications in human patients with
obesity. Articles were searched using Pubmed and Clinical Key as search engines. To select only
articles that were relevant for our investigation the boolean terminology ((Akkermansia muciniphila)
AND (obesity)) AND (intervention, OR nutrition, OR diet, OR nutrient, OR nutrients) was applied.
The 208 original articles found were sorted to select only those with human dietary interventions.
Results show that the increase of A. muciniphila (whether through direct supplementation or by
dietary intervention) was beneficial to decreasing inflammation, reducing cardiovascular risk,
increasing insulin sensitivity and lowering cholesterol levels. It was concluded that further
interventions in human subjects are needed to ascertain the benefits and risks of increased A.
muciniphila concentrations