Urinary metabolomic profile of neonates born to women with gestational diabetes mellitus

Ana Sofía Herrera Van Oostdam, Mariana Salgado-Bustamante, Victoria Lima-Rogel, Juan José Oropeza-Valdez, Jesús Adrián López, Iván Daniel Román Rodríguez, Juan Carlos Toro-Ortiz, David Alejandro Herrera Van Oostdam, Yamilé López-Hernández*, Joel Monárrez-Espino

*Autor correspondiente de este trabajo

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3 Citas (Scopus)


Gestational diabetes mellitus (GDM) is one of the most frequent pregnancy complications with potential adverse outcomes for mothers and newborns. Its effects on the newborn appear during the neonatal period or early childhood. Therefore, an early diagnosis is crucial to prevent the development of chronic diseases later in adult life. In this study, the urinary metabolome of babies born to GDM mothers was characterized. In total, 144 neonatal and maternal (second and third trimesters of pregnancy) urinary samples were analyzed using targeted metabolomics, com-bining liquid chromatographic mass spectrometry (LC-MS/MS) and flow injection analysis mass spectrometry (FIA-MS/MS) techniques. We provide here the neonatal urinary concentration values of 101 metabolites for 26 newborns born to GDM mothers and 22 newborns born to healthy mothers. The univariate analysis of these metabolites revealed statistical differences in 11 metabolites. Multi-variate analyses revealed a differential metabolic profile in newborns of GDM mothers characterized by dysregulation of acylcarnitines, amino acids, and polyamine metabolism. Levels of hexadecenoyl-carnitine (C16:1) and spermine were also higher in newborns of GDM mothers. The maternal urinary metabolome revealed significant differences in butyric, isobutyric, and uric acid in the second and third trimesters of pregnancy. These metabolic alterations point to the impact of GDM in the neonatal period.
Idioma originalEnglish
Número de artículo723
EstadoPublished - nov 2021

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Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Endocrinología, diabetes y metabolismo
  • Bioquímica
  • Biología molecular


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