Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

Adriana Sampayo-Reyes, Reyes S. Taméz-Guerra, Mario Bermúdez de León, Javier Vargas-Villarreal, Héctor Gerardo Lozano-Garza, Cristina Rodríguez-Padilla, Constanza Cortés, Ricard Marcos, Alba Hernández

Resultado de la investigaciónrevisión exhaustiva

5 Citas (Scopus)


Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

Idioma originalEnglish
Páginas (desde-hasta)204-211
Número de páginas8
PublicaciónReproductive Toxicology
EstadoPublished - 1 dic 2017
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Toxicología


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