Temperature Differences Between Controlled Primary Hypothyroidism and Healthy Patients: An Exploratory Study

Maria Elena Romero-Ibarguengoitia*, Arnulfo Garza-Silva, Andrea Rivera-Cavazos, Devany Paola Morales-Rodriguez, Omar Israel González-Peña, Irene Antonieta Barco-Flores, Edgar Manilla Muñoz, Enrique Villarreal-Leal, Arnulfo González-Cantú

*Autor correspondiente de este trabajo

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Introduction: Hypothyroidism is conventionally treated with replacement therapy through levothyroxine (LT4). Despite the improvement in symptoms, cold intolerance persists in some patients. The present study aims to determine whether there is a difference in temperature perception and skin temperature between patients with primary controlled hypothyroidism (PCH) and a group of healthy controls matched for body mass index and age. Secondarily we aimed to determine difference in quality of life. Methodology: Skin temperature measurements were performed in both groups, both in the central and peripheral regions of the body. In addition, subjects were asked about their perception of temperature in a temperature-controlled room; anthropometric measurements were taken, their quality of life was assessed using the ThyPRO-39, and a thyroid hormone profile was performed. Results: Eleven patients in the PCH group and 30 patients in the control group were studied. It was found that the group with PCH presented a significantly lower palmar temperature than the control group [mean (SD) of 32.05 (1.79) vs 33.10 (1.30) oC, P = .046]. A mediation model showed a direct effect. Temperature perception was equal between groups. The median (interquartile range) of ThyPRO was 8 (5.2) points in the control group vs 21.8 (13.5) in the group of controlled hypothyroidism, P < .001. Discussion: These results suggest that, despite LT4 treatment, patients continue to present abnormalities in thermogenesis-related thermogenesis, and this may be due to a lack of hormonal adaptation to environmental changes and physiological demands, leading to lower body temperatures and increased sensitivity to cold.

Idioma originalEnglish
Número de artículo8
Páginas (desde-hasta)bvad175
PublicaciónJournal of the Endocrine Society
EstadoPublished - 1 feb 2024

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© 2024 Oxford University Press. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Endocrinología, diabetes y metabolismo


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