Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

B.E. Hawkins, S. Krishnamurthy, D.L. Castillo-Carranza, U. Sengupta, D.S. Prough, G.R. Jackson, D.S. DeWitt, R. Kayed

Resultado de la investigaciónrevisión exhaustiva

92 Citas (Scopus)

Resumen

Traumatic brain injury (TBI) is a serious problem that affects millions of people in the United States alone. Multiple concussions or even a single moderate to severe TBI can also predispose individuals to develop a pathologically distinct form of tauopathy-related dementia at an early age. No effective treatments are currently available for TBI or TBI-related dementia; moreover, only recently has insight been gained regarding the mechanisms behind their connection. Here, we used antibodies to detect oligomeric and phosphorylated Tau proteins in a non-transgenic rodent model of parasagittal fluid percussion injury. Oligomeric and phosphorylated Tau proteins were detected 4 and 24 h and 2 weeks post-TBI in injured, but not sham control rats. These findings suggest that diagnostic tools and therapeutics that target only toxic forms of Tau may provide earlier detection and safe, more effective treatments for tauopathies associated with repetitive neurotrauma.

Idioma originalEnglish
Páginas (desde-hasta)17042-17050
Número de páginas9
PublicaciónJournal of Biological Chemistry
Volumen288
N.º23
DOI
EstadoPublished - 7 jun 2013
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Bioquímica
  • Biología molecular
  • Biología celular

Huella

Profundice en los temas de investigación de 'Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies'. En conjunto forman una huella única.

Citar esto