Preparation and characterization of neurotoxic tau oligomers

C.A. Lasagna-Reeves, D.L. Castillo-Carranza, M.J. Guerrero-Muñoz, G.R. Jackson, R. Kayed

Resultado de la investigaciónrevisión exhaustiva

223 Citas (Scopus)

Resumen

Tau aggregation is a pathological hallmark of Alzheimer's disease, Parkinson's disease, and many other neurodegenerative disorders known as tauopathies. Tau aggregates take on many forms, and their formation is a multistage process with intermediate stages. Recently, tau oligomers have emerged as the pathogenic species in tauopathies and a possible mediator of amyloid-β toxicity in Alzheimer's disease. Here, we use a novel, physiologically relevant method (oligomer cross-seeding) to prepare homogeneous populations of tau oligomers and characterize these oligomers in vitro. We show that both Aβ and α-synuclein oligomers induce tau aggregation and the formation of β-sheet-rich neurotoxic tau oligomers.

Idioma originalEnglish
Páginas (desde-hasta)10039-10041
Número de páginas3
PublicaciónBiochemistry
Volumen49
N.º47
DOI
EstadoPublished - 30 nov 2010
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Bioquímica

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