Physical Performance in Elderly Outpatients with Subclinical Hypothyroidism Compared with Euthyroid Counterparts

Abraham A. Vázquez-García, Lilia Cárdenas-Ibarra*, Jesús Z. Villarreal-Pérez, Sandra Veronica Meza Cavazos, Daniel Gamez, Jorge Platt, Guillermo Guajardo-Álvarez, David Saucedo, Francisco Torres-Pérez

*Autor correspondiente de este trabajo

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Background: There continues to be controversy on the clinical relevance of elderly mild subclinical hypothyroidism (SH), defined as a TSH elevation (4.0-9.99 µIU/L) with normal free thyroxin levels. Objective: To compare physical performance (PP) in elderly individuals with a TSH level above normal range versus normal counterparts. Design: Case-control study of ambulatory patients enrolled between January 2009 and December 2010. Setting: Outpatient geriatric service. Participants: Elderly individuals 65-84 years old (y/o) with SH and without conditions known to affect physical mobility. Measurements: The Short Physical Performance Battery (SPPB) was performed. The statistical analysis used the Mantel-Haenszel odds ratio (M-H-OR) method and Student’s t test with an alpha of 0.05. Results: Of the 183 individuals screened, 28 (15.3%) had SH. The study response was 89.3%, thus 25 individuals with SH were compared to 27 euthyroid controls matched by age and sex. Gender and age influence SPPB, increased age was associated with <4 points balance: 13.8% in 65-74 y/o vs. 44.0% in 75-84 y/o, χ2=6.1, p<0.05; strength of dominant leg and SPPB score were higher in men than women (both, p<0.05). Body mass index was higher in SH than controls in men (29.3 ± 2 vs. 23.4 ± 3, t=3.2, <0.02). Women with SH had a worse SPPB score than the control group, M-H-OR=8.4, p<0.05. Confidence intervals of mean gait speed were 0.73-0.95 vs. 0.98-1.14 m/s, respectively with results in men lacking significance. Chair stands were longer in SH than controls: 13.5 ± 2.4 vs. 10.0 ± 1.7 seconds for men and 20.6 ± 12.6 vs. 14.8 ± 2.9 seconds for women, both p<0.05. Conclusions: These data suggests an association between SH and lower physcial performance. This warrants further study to define if T4 supplementation improves physcial performance, thus preventing frailty.
Idioma originalEnglish
PublicaciónJournal of Thyroid Disorders & Therapy
EstadoPublished - 2017
Publicado de forma externa


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