Photolyase Production and Current Applications: A Review

Diana Ramírez-Gamboa, Ana Laura Díaz-Zamorano, Edgar Ricardo Meléndez-Sánchez, Humberto Reyes-Pardo, Karen Rocio Villaseñor-Zepeda, Miguel E. López-Arellanes, Juan Eduardo Sosa-Hernández, Karina G. Coronado-Apodaca, Ana Gámez-Méndez, Samson Afewerki, Hafiz M.N. Iqbal, Roberto Parra-Saldivar*, Manuel Martínez-Ruiz

*Autor correspondiente de este trabajo

Producción científicarevisión exhaustiva

9 Citas (Scopus)

Resumen

The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct can lead to multiple affections such as cellular apoptosis and mutagenesis that can evolve into skin cancer. The development of integrated applications to prevent the negative effects of prolonged sunlight exposure, usually during outdoor activities, is imperative. This study presents the functions, characteristics, and types of photolyases, their therapeutic and cosmetic applications, and additionally explores some photolyase-producing microorganisms and drug delivery systems. © 2022 by the authors.
Idioma originalEnglish
Número de artículo5998
PublicaciónMolecules
Volumen27
N.º18
DOI
EstadoPublished - sept 2022

Nota bibliográfica

Publisher Copyright:
© 2022 by the authors.

All Science Journal Classification (ASJC) codes

  • Química analítica
  • Química (miscelánea)
  • Medicina molecular
  • Ciencias farmacéuticas
  • Descubrimiento de medicamentos
  • Química física y teórica
  • Química orgánica

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