TY - JOUR
T1 - Photolyase Production and Current Applications
T2 - A Review
AU - Ramírez-Gamboa, Diana
AU - Díaz-Zamorano, Ana Laura
AU - Meléndez-Sánchez, Edgar Ricardo
AU - Reyes-Pardo, Humberto
AU - Villaseñor-Zepeda, Karen Rocio
AU - López-Arellanes, Miguel E.
AU - Sosa-Hernández, Juan Eduardo
AU - Coronado-Apodaca, Karina G.
AU - Gámez-Méndez, Ana
AU - Afewerki, Samson
AU - Iqbal, Hafiz M.N.
AU - Parra-Saldivar, Roberto
AU - Martínez-Ruiz, Manuel
N1 - Funding Information:
This work was also partially supported by Consejo Nacional de Ciencia y Tecnología (CONACYT) under Sistema Nacional de Investigadores (SNI) program awarded to Manuel Martínez Ruiz (CVU: 418151), Juan Eduardo Sosa-Hernández (CVU: 375202), Roberto Parra-Saldívar (CVU: 35753) and Hafiz M.N. Iqbal (CVU: 735340). Figures were created with BioRender.com.
Funding Information:
This research was supported by NET ZERO RESEARCH FUND (2021 call) from The Bank of Nova Scotia. The funding number is not applicable.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct can lead to multiple affections such as cellular apoptosis and mutagenesis that can evolve into skin cancer. The development of integrated applications to prevent the negative effects of prolonged sunlight exposure, usually during outdoor activities, is imperative. This study presents the functions, characteristics, and types of photolyases, their therapeutic and cosmetic applications, and additionally explores some photolyase-producing microorganisms and drug delivery systems.
AB - The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct can lead to multiple affections such as cellular apoptosis and mutagenesis that can evolve into skin cancer. The development of integrated applications to prevent the negative effects of prolonged sunlight exposure, usually during outdoor activities, is imperative. This study presents the functions, characteristics, and types of photolyases, their therapeutic and cosmetic applications, and additionally explores some photolyase-producing microorganisms and drug delivery systems.
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U2 - 10.3390/molecules27185998
DO - 10.3390/molecules27185998
M3 - Review article
C2 - 36144740
AN - SCOPUS:85138349014
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 18
M1 - 5998
ER -
