Oral guaifenesin for treatment of filamentary keratitis: A pilot study

Giulia Coco, Francisco Amparo, Sangita P. Patel, William Foulsham, Jimena Tatiana Carreno-Galeano, Steven G. Stockslager, Joseph B. Ciolino, Jia Yin, Reza Dana

Resultado de la investigación

Resumen

Purpose: Pilot study to evaluate the safety and efficacy of oral guaifenesin in reducing the signs and symptoms of filamentary keratitis. Methods: Prospective, uncontrolled open-label pilot study. Twelve patients with non-Sjögren dry eye disease (DED) and secondary filamentary keratitis received treatment with oral guaifenesin 600 mg twice a day (total dose of 1.2 g/day) for 4 weeks. Adverse events, change in the number of corneal filaments, corneal fluorescein staining (CFS; NEI grading system), and symptoms (Ocular Surface Disease Index) were assessed. Results: Before starting oral guaifenesin, all patients were on topical medical therapy for their condition. At baseline, the mean number of filaments was 5.8 ± 2.9, CFS score 7.3 ± 3.2, and OSDI score 55.6 ± 25. After 4 weeks of treatment, the number of filaments was 2.1 ± 2.2 (p = 0.04 vs. baseline), CFS score 6.5 ± 3.1 (p = 0.5), and OSDI score 46.1 ± 30.9 (p = 0.2). One patient discontinued the medication due to gastrointestinal side effects. Conclusions: Oral guaifenesin was safe and generally well tolerated, and demonstrated modest efficacy in reducing the severity of filamentary keratitis. These results should be considered preliminary; however, placebo-controlled investigations would be justified to evaluate the therapeutic efficacy of oral guaifenesin as a mucolytic in treatment of filamentary keratitis.

Idioma originalEnglish
Páginas (desde-hasta)565-570
Número de páginas6
PublicaciónOcular Surface
Volumen17
N.º3
DOI
EstadoPublished - jul 2019
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Huella Profundice en los temas de investigación de 'Oral guaifenesin for treatment of filamentary keratitis: A pilot study'. En conjunto forman una huella única.

  • Citar esto

    Coco, G., Amparo, F., Patel, S. P., Foulsham, W., Carreno-Galeano, J. T., Stockslager, S. G., Ciolino, J. B., Yin, J., & Dana, R. (2019). Oral guaifenesin for treatment of filamentary keratitis: A pilot study. Ocular Surface, 17(3), 565-570. https://doi.org/10.1016/j.jtos.2019.03.008