Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.
|Número de páginas||3|
|Publicación||The Israel Medical Association journal : IMAJ|
|Estado||Published - 1 feb 2001|
|Publicado de forma externa||Sí|
All Science Journal Classification (ASJC) codes