Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine

Thiago Malagrino , Anna Godoy, Juliano Barbosa, Abner Lima, Nei Souza, Jairo Pedrotti, Pamela Garcia, Roberto Paniago, Lidia Andrade, Sergio Domingues, Wellington Silva, Helio Ribeiro, Jaime Taha-Tijerina

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Resumen

In this work, flower-like molybdenum disulfide (MoS 2 ) microspheres were produced with polyethylene glycol (PEG) to form MoS 2-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS 2-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS 2-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS 2-PEG and MoS 2-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.

Idioma originalEnglish
Número de artículo2053
Páginas (desde-hasta)2053
Número de páginas18
PublicaciónNanomaterials
Volumen12
N.º12
DOI
EstadoPublished - 1 jun 2022

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