METHOD FOR DETECTING THE POLYMORPHISM GSTM3 A/B IN HUMAN DNA SAMPLES

Rafael B R Leon-Cachon, María Guadalupe Moreno Treviño, Denisse Aideé Martínez-Treviño

Resultado de la investigación

Resumen

The invention presented here, consists of a method for detecting the GSTM3 A/B polymorphism in human DNA samples, which has been associated with various types of cancer in various populations. The method consists of two probes specific for two sequences, one that is complementary to the wild-type allele (without deletion) and another complementary to the allele with the deletion. The present invention also comprises two specific primers/primers for amplifying the target sequence. The method in question allows the development of more association studies of the GSTM3 A/B polymorphism in a simpler, faster, more sensitive and economic way than the methods currently used such as PCR-RFLP and nuecleotide sequencing.
Idioma originalEnglish
CIPMX/a/2017/009634
EstadoE-pub ahead of print - 15 mar 2019

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