The invention presented here, consists of a method for detecting the GSTM3 A/B polymorphism in human DNA samples, which has been associated with various types of cancer in various populations. The method consists of two probes specific for two sequences, one that is complementary to the wild-type allele (without deletion) and another complementary to the allele with the deletion. The present invention also comprises two specific primers/primers for amplifying the target sequence. The method in question allows the development of more association studies of the GSTM3 A/B polymorphism in a simpler, faster, more sensitive and economic way than the methods currently used such as PCR-RFLP and nuecleotide sequencing.
|Estado||E-pub ahead of print - 15 mar 2019|
Leon-Cachon, R. B. R., Moreno Treviño, M. G., & Martínez-Treviño, D. A. (2019). N.º de IPC MX/a/2017/009634. METHOD FOR DETECTING THE POLYMORPHISM GSTM3 A/B IN HUMAN DNA SAMPLES. Instituto Mexicano de la Propiedad Industrial. http://vidoc.impi.gob.mx/visor?usr=SIGA&texp=SI&tdoc=E&id=MX%2fa%2f2017%2f009634