Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización

Jorge Bátiz-Armenta, Andrea Ferranti Ramos, Gerardo Francisco Javier Rivera Silva, Guillermo H. Martínez-Delgado, Francisco De la Garza Alvarez, Héctor R. Martínez-Menchaca

Resultado de la investigaciónrevisión exhaustiva

Resumen

Introduction: Matrix metalloproteinases are essential for structural maintenance of extracellular matrix enzymes, as well as degradation in situations where tissue repair process is warranted. Objective: To review the most current aspects of matrix metalloproteinases and their role in the healing process. Research Methodology: A review of about 95 papers was conducted during the period from July 18, 2015 to September 20, 2016; PubMed, Scopus, Scielo and Science Direct were used. Results: There are six subfamilies of metalloproteinases: collagenases, stromalysins, elastases, gelatinases, matrilysins and metalloproteinases associated with the plasma membrane. Vascular endothelial cells secrete them where there is epithelial damage and a healing process is required. Conclusions: Metalloproteinases are zinc dependent endopeptidases that are essential for the maintenance and degradation of the extracellular matrix. When the adjustment mechanism fails and matrix metalloproteinases are overexpressed, poor healing processes occur, causing problems such as liver chronic wounds, keloids or hypertrophic scars, pterygium, pulmonary and liver fibrosis, among other clinical conditions. (English) [ABSTRACT FROM AUTHOR]
Idioma originalEnglish
Páginas (desde-hasta)55-62
Número de páginas8
PublicaciónRevista Médicas UIS
Volumen30
N.º3
DOI
EstadoPublished - 20 dic 2017

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