Mapeo por inmunofluorescencia para el diagnóstico de epidermólisis ampollosa congénita

R. Cepeda-Valdés, G. Pohla-Gubo, J. R. Borbolla-Escoboza, O. Barboza-Quintana, J. Ancer-Rodríguez, H. Hintner, J. C. Salas-Alanis

Resultado de la investigaciónrevisión exhaustiva

17 Citas (Scopus)

Resumen

The tools for diagnosis of epidermolysis bullosa have advanced greatly since Hintner's group introduced antigen mapping as a diagnostic test for this family of genodermatoses. Monoclonal or polyclonal antibodies raised against some of the specific proteins found in the epidermis and basement membrane of the epidermis have allowed 4 types of epidermolysis bullosa de be identified and all variants to be classified. When a newborn baby presents with blisters, many conditions are implicated in the differential diagnosis. Examination under an optical microscope can suggest epidermolysis bullosa, but immunofluorescence mapping and electron microscopy are required for confirmation of the diagnosis and further classification of congenital epidermolysis bullosa. This article explains the importance of immunofluorescence antigen mapping and describes the methods employed for classification and subclassification of epidermolysis bullosa.

Idioma originalSpanish
Páginas (desde-hasta)673-682
Número de páginas10
PublicaciónActas Dermo-Sifiliograficas
Volumen101
N.º8
DOI
EstadoPublished - oct 2010
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Patología y medicina forense
  • Histología
  • Dermatología

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