Loading of doxorubicin on poly(methyl methacrylate-co-methacrylic acid) nanoparticles and release study

Roberto López-Muñoz *, María Ester Treviño , Fabiola Castellanos, Graciela Morales, Oliverio Rodriguez Fernandez, Santiago Saavedra Alonso, Angel Licea Claverie, Hened Saade, Francisco Javier Enriquez Medrano , Raúl Guillermo López

*Autor correspondiente de este trabajo

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Resumen

Nanoparticles (NP) of 12.7 nm in diameter of the poly(methyl methacrylate (MMA)-co-methacrylic acid (MAA)) copolymer were prepared. 13C-NMR results showed a MMA:MAA molar ratio of 0.64:0.36 in the copolymer, which is similar to the poly(MMA-co-MAA) commercially known as the FDA approved Eudragit S100 (0.67:0.33). The NP prepared in this study were loaded at pH 5 with varying amounts (from 0.54 to 6.91%) of doxorubicin (DOX), an antineoplastic drug. 1H-NMR results indicated the electrostatic interactions between the ionized carboxylic groups of the MAA units in the copolymer and the proton of the glycosidic amine in DOX. Measurements by QLS and TEM indicated that the loading destabilizes the NP, and that for increase stability, they aggregate in a reversible way, forming aggregates with a diameter up to 99.5 nm at a DOX load of 6.91%. The analysis of drug release data at pH 7.4 showed that loaded NP with at least 4.38% DOX release the drug very slowly and follows the Higuchi model; the former suggests that they could remain for long periods in the bloodstream to reach and destroy cancer cells.
Idioma originalEnglish
Páginas (desde-hasta)1107-1124
Número de páginas18
PublicaciónJournal of biomaterials science. Polymer edition
Volumen32
N.º9
DOI
EstadoPublished - 28 mar 2021
Publicado de forma externa

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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