Liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells

Florent Duval, Jorge E. Moreno-Cuevas, Maria Teresa González-Garza, Carlos Rodríguez-Montalvo, Delia Elva Cruz-Vega

Resultado de la investigaciónrevisión exhaustiva

31 Citas (Scopus)

Resumen

Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. This review will describe the role of hepatocytes and HSC in the pathogenesis of liver fibrosis and detail the mechanisms of modulation of apoptosis of both cell lines by twelve known hepatoprotective plants in order to reduce liver fibrosis.

Idioma originalEnglish
Número de artículo373295
PublicaciónAdvances in Pharmacological Sciences
Volumen2014
DOI
EstadoPublished - 2014
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Medicina molecular
  • Farmacología, toxicología y ciencias farmacéuticas (todo)
  • Farmacología (médica)

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