Individual response to drug therapy: Bases and study approaches

Rafael Baltazar Reyes Leoń-Cachón, Jorge Ángel Ascacio-Martínez, Hugo Alberto Barrera-Saldaña

Resultado de la investigaciónrevisión exhaustiva

11 Citas (Scopus)

Resumen

Genomic variation largely explains the differences in an individual's response to drug treatments. A field of genomic medicine focuses on the identification of genetic polymorphisms and gene mutations involved in the development and progression of disease. Another part focuses on the development of genetic tests to accompany medical prescriptions, to predict how certain patients respond to therapy with a given pharmacological agent. The field of predicting responses to drugs has different strategies and methods, among which we find: the use of liver microsomes, cell models, monitoring of probe drugs, assays with recombinant proteins and recently the use of microarray platforms or DNAchips.
Idioma originalEnglish
Páginas (desde-hasta)364-376
Número de páginas13
PublicaciónRevista de Investigacion Clinica
Volumen64
N.º4
EstadoPublished - 1 jul 2012
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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