Incremento de las citoquinas proteína quimiotáctica de monocitos-1 (MCP-1) y proteína inflamatoria macrofágica-1β (MIP-1β) en líquido cefalorraquídeo de pacientes con esclerosis lateral amiotrófica

H. R. Martínez, C. E. Escamilla-Ocañas, C. R. Camara-Lemarroy, M. T. González-Garza, J. Moreno-Cuevas, M. A. García Sarreón

Resultado de la investigaciónrevisión exhaustiva

2 Citas (Scopus)

Resumen

Introduction: Neuroinflammation has recently been described in amyotrophic lateral sclerosis (ALS). However, the precise role of such proinflammatory cytokines as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in ALS has not yet been determined. In this study, we determined cerebrospinal fluid (CSF) MCP-1 and MIP-1β levels and assessed their association with the duration and severity of ALS. Methods: Concentrations of MCP-1 and MIP-1β were determined in the CSF of 77 patients diagnosed with ALS and 13 controls. Cytokine levels were analysed in relation to ALS duration (< 12 months vs. > 12 months) and severity (< 30 points vs. > 30 points on the ALS Functional Rating Scale administered at hospital admission). Results: Higher CSF MIP-1β (10.68 pg/mL vs. 4.69 pg/mL, P < .0001) and MCP-1 (234.89 pg/mL vs. 160.95 pg/mL, P = .011) levels were found in the 77 patients with ALS compared to controls. There were no differences in levels of either cytokine in relation to disease duration or severity. However, we did observe a significant positive correlation between MIP-1β and MCP-1 in patients with ALS. Conclusions: The increase in MIP-1β and MCP-1 levels suggests that these cytokines may have a synergistic effect on ALS pathogenesis. However, in our cohort, no association was found with either the duration or the clinical severity of the disease. © 2017 Sociedad Española de Neurología
Título traducido de la contribuciónIncreased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis
Idioma originalSpanish
Páginas (desde-hasta)165-169
Número de páginas5
PublicaciónNeurologia
Volumen35
N.º3
DOI
EstadoPublished - abr 2020
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2017 Sociedad Española de Neurología

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

  • Neurología clínica

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