TY - JOUR
T1 - In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts
AU - Montoya, Alexandra M.
AU - Luna-Rodríguez, Carolina E.
AU - Gracia-Robles, Gabriela
AU - Rojas, Olga C.
AU - González, Gloria M.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).
AB - Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).
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U2 - 10.1007/s00203-019-01684-2
DO - 10.1007/s00203-019-01684-2
M3 - Article
VL - 201
SP - 1147
EP - 1149
JO - Archives of Microbiology
JF - Archives of Microbiology
SN - 0302-8933
IS - 8
ER -