In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts

Alexandra M. Montoya, Carolina E. Luna-Rodríguez, Gabriela Gracia-Robles, Olga C. Rojas, Gloria M. González

Resultado de la investigación

Resumen

Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).
Idioma originalEnglish
Páginas (desde-hasta)1147-1149
Número de páginas3
PublicaciónArchives of Microbiology
Volumen201
N.º8
DOI
EstadoPublished - 1 oct 2019

    Huella digital

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Biochemistry
  • Molecular Biology
  • Genetics

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