TY - JOUR
T1 - Actividad inhibitoria in vitro de la sertralina frente a aislamientos clínicos de Sporothrix schenckii
AU - Rojas García, Olga Carolina
AU - Villanueva Lozano, Hiram
AU - Treviño Rangel, Rogelio de J.
AU - Téllez-Marroquín, Ricardo
AU - Bonifaz, Alexandro
AU - Hernández Rodríguez, Pedro A.
AU - González, Gloria María
N1 - Funding Information:
This work was supported by internal resources of the Department of Microbiology, School of Medicine, UANL .
Publisher Copyright:
© 2019 Asociación Española de Micología
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus, Coccidioides, Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifungals. Aims: In our study we evaluate the antifungal activity of SRT, alone and in combination with itraconazole (ITC), voriconazole (VRC) and amphotericin B (AMB), against 15 clinical isolates of Sporothrix schenckii. Methods: We used the broth microdilution method as described by the CLSI to test the susceptibility to antifungals, and the checkerboard microdilution method to evaluate drug interactions. Results: The minimum inhibitory concentration (MIC) with SRT was in the range of 4–8 μg/ml, while for AMB, VRC and ITC were 0.5–4 μg/ml, 0.5–8 μg/ml and 0.125–2 μg/ml, respectively. In addition, SRT showed synergy with ITC in one strain, mainly additivity with VRC, and indifference with AMB in others. Conclusions: The MIC values with SRT for the isolates studied show the potential role of this drug as an adjuvant in the treatment of sporotrichosis, especially in disseminated or complicated cases.
AB - Background: Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus, Coccidioides, Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifungals. Aims: In our study we evaluate the antifungal activity of SRT, alone and in combination with itraconazole (ITC), voriconazole (VRC) and amphotericin B (AMB), against 15 clinical isolates of Sporothrix schenckii. Methods: We used the broth microdilution method as described by the CLSI to test the susceptibility to antifungals, and the checkerboard microdilution method to evaluate drug interactions. Results: The minimum inhibitory concentration (MIC) with SRT was in the range of 4–8 μg/ml, while for AMB, VRC and ITC were 0.5–4 μg/ml, 0.5–8 μg/ml and 0.125–2 μg/ml, respectively. In addition, SRT showed synergy with ITC in one strain, mainly additivity with VRC, and indifference with AMB in others. Conclusions: The MIC values with SRT for the isolates studied show the potential role of this drug as an adjuvant in the treatment of sporotrichosis, especially in disseminated or complicated cases.
UR - http://www.scopus.com/inward/record.url?scp=85066410392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066410392&partnerID=8YFLogxK
U2 - 10.1016/j.riam.2019.01.004
DO - 10.1016/j.riam.2019.01.004
M3 - Article
VL - 36
SP - 139
EP - 141
JO - Revista Iberoamericana de Micologia
JF - Revista Iberoamericana de Micologia
SN - 1130-1406
IS - 3
ER -