Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats

Carlos Rodrigo Cámara-Lemarroy, Francisco Javier Guzmán-de la Garza, Gabriela Alarcón-Galván, Paula Cordero-Pérez, Linda Muñoz-Espinosa, Liliana Torres-González, Nancy Esthela Fernández-Garza

Resultado de la investigaciónrevisión exhaustiva

16 Citas (Scopus)

Resumen

Background and Aims: Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1). Methods: Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured. Results: After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores. Conclusions: Our results show that ATOR protects the liver from I/R injury.

Idioma originalEnglish
Páginas (desde-hasta)210-216
Número de páginas7
PublicaciónArchives of Medical Research
Volumen45
N.º3
DOI
EstadoPublished - abr 2014
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Medicina (todo)

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