TY - JOUR
T1 - Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans
AU - Mendoza-Cantú, Ania
AU - Castorena-Torres, Fabiola
AU - Bermudez, Mario
AU - Martínez-Hernández, Roberto
AU - Ortega, Arturo
AU - Salinas, Juan E.
AU - Albores, Arnulfo
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - CYP1A2 and CYP2E1 are two of the main cytochrome P450 isoforms involved in the metabolism of commonly used drugs and xenobiotic compounds considered to be responsible for or possible participants in the development of several human diseases. Individual susceptibility to developing these pathologies relies, among other factors, on genetic polymorphism which depends on ethnic differences, as the frequency of mutant genotypes varies in different human populations. Thus the aim of this study was to investigate the frequency of CYP1A2 5′-flanking region and CYP2E1 Rsa I/Pst I polymorphisms in Mexicans by PCR-RFLP methods. The DNA of 159 subjects was analysed and mutant allele frequencies of 30% for CYP2E1 Rsa I/Pst I sites and 43% for CYP1A2 5′-flanking region were found. These frequencies are higher than those previously reported for other human populations.
AB - CYP1A2 and CYP2E1 are two of the main cytochrome P450 isoforms involved in the metabolism of commonly used drugs and xenobiotic compounds considered to be responsible for or possible participants in the development of several human diseases. Individual susceptibility to developing these pathologies relies, among other factors, on genetic polymorphism which depends on ethnic differences, as the frequency of mutant genotypes varies in different human populations. Thus the aim of this study was to investigate the frequency of CYP1A2 5′-flanking region and CYP2E1 Rsa I/Pst I polymorphisms in Mexicans by PCR-RFLP methods. The DNA of 159 subjects was analysed and mutant allele frequencies of 30% for CYP2E1 Rsa I/Pst I sites and 43% for CYP1A2 5′-flanking region were found. These frequencies are higher than those previously reported for other human populations.
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U2 - 10.1002/cbf.1049
DO - 10.1002/cbf.1049
M3 - Article
VL - 22
SP - 29
EP - 34
JO - Cell Biochemistry and Function
JF - Cell Biochemistry and Function
SN - 0263-6484
IS - 1
ER -