Frequency of the CCR5 gene 32-basepair deletion in Hispanic Mexicans

J. C. Salas-Alanis, J. E. Mellerio, G. H.S. Ashton, John A. McGrath

Resultado de la investigación

6 Citas (Scopus)

Resumen

A 32-basepair deletion polymorphism in the CCR5 chemokine receptor gene (ΔCCR5) has recently been identified and shown to have functional significance in determining susceptibility to infection by human immunodeficiency virus type 1 (HIV-1) and a possible influence on disease progression in HIV-1-positive individuals. Interest has also focused on the geographical distribution of the ΔCCR5 allele, particularly in considering epidemiological aspects of HIV disease and its impact on health economics. In this report we have assessed the frequency of the ΔCCR5 allele in a Hispanic Mexican population and found a gene frequency of 4.4% in 103 individuals. The ΔCCR5 allele is not present in indigenous Mexican populations but is present in about 8% of the population in Spain. Gene flow from the European gene pool consistent with Mexico's colonial past would account for the findings in this study.
Idioma originalEnglish
Páginas (desde-hasta)127-129
Número de páginas3
PublicaciónClinical and Experimental Dermatology
DOI
EstadoPublished - 22 may 1999
Publicado de forma externa

Huella dactilar

Hispanic Americans
Gene Frequency
HIV-1
Alleles
CCR5 Receptors
Gene Pool
Gene Flow
Chemokine Receptors
Mexico
Population Groups
Spain
Population
Disease Progression
Economics
HIV
Health
Infection
Genes

All Science Journal Classification (ASJC) codes

  • Dermatology

Citar esto

Salas-Alanis, J. C. ; Mellerio, J. E. ; Ashton, G. H.S. ; McGrath, John A. / Frequency of the CCR5 gene 32-basepair deletion in Hispanic Mexicans. En: Clinical and Experimental Dermatology. 1999 ; pp. 127-129.
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title = "Frequency of the CCR5 gene 32-basepair deletion in Hispanic Mexicans",
abstract = "A 32-basepair deletion polymorphism in the CCR5 chemokine receptor gene (ΔCCR5) has recently been identified and shown to have functional significance in determining susceptibility to infection by human immunodeficiency virus type 1 (HIV-1) and a possible influence on disease progression in HIV-1-positive individuals. Interest has also focused on the geographical distribution of the ΔCCR5 allele, particularly in considering epidemiological aspects of HIV disease and its impact on health economics. In this report we have assessed the frequency of the ΔCCR5 allele in a Hispanic Mexican population and found a gene frequency of 4.4{\%} in 103 individuals. The ΔCCR5 allele is not present in indigenous Mexican populations but is present in about 8{\%} of the population in Spain. Gene flow from the European gene pool consistent with Mexico's colonial past would account for the findings in this study.",
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Frequency of the CCR5 gene 32-basepair deletion in Hispanic Mexicans. / Salas-Alanis, J. C.; Mellerio, J. E.; Ashton, G. H.S.; McGrath, John A.

En: Clinical and Experimental Dermatology, 22.05.1999, p. 127-129.

Resultado de la investigación

TY - JOUR

T1 - Frequency of the CCR5 gene 32-basepair deletion in Hispanic Mexicans

AU - Salas-Alanis, J. C.

AU - Mellerio, J. E.

AU - Ashton, G. H.S.

AU - McGrath, John A.

PY - 1999/5/22

Y1 - 1999/5/22

N2 - A 32-basepair deletion polymorphism in the CCR5 chemokine receptor gene (ΔCCR5) has recently been identified and shown to have functional significance in determining susceptibility to infection by human immunodeficiency virus type 1 (HIV-1) and a possible influence on disease progression in HIV-1-positive individuals. Interest has also focused on the geographical distribution of the ΔCCR5 allele, particularly in considering epidemiological aspects of HIV disease and its impact on health economics. In this report we have assessed the frequency of the ΔCCR5 allele in a Hispanic Mexican population and found a gene frequency of 4.4% in 103 individuals. The ΔCCR5 allele is not present in indigenous Mexican populations but is present in about 8% of the population in Spain. Gene flow from the European gene pool consistent with Mexico's colonial past would account for the findings in this study.

AB - A 32-basepair deletion polymorphism in the CCR5 chemokine receptor gene (ΔCCR5) has recently been identified and shown to have functional significance in determining susceptibility to infection by human immunodeficiency virus type 1 (HIV-1) and a possible influence on disease progression in HIV-1-positive individuals. Interest has also focused on the geographical distribution of the ΔCCR5 allele, particularly in considering epidemiological aspects of HIV disease and its impact on health economics. In this report we have assessed the frequency of the ΔCCR5 allele in a Hispanic Mexican population and found a gene frequency of 4.4% in 103 individuals. The ΔCCR5 allele is not present in indigenous Mexican populations but is present in about 8% of the population in Spain. Gene flow from the European gene pool consistent with Mexico's colonial past would account for the findings in this study.

U2 - 10.1046/j.1365-2230.1999.00432.x

DO - 10.1046/j.1365-2230.1999.00432.x

M3 - Article

SP - 127

EP - 129

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

SN - 0307-6938

ER -