Evaluation of DNA damage in obese children using the chromatin dispersion test

Martha I. Dávila-Rodríguez, Francisco González-Salazar, Manuel López-Cabanillas, Ricardo M. Cerda-Flores, Elva I. Cortés-Gutiérrez*

*Autor correspondiente de este trabajo

Producción científicarevisión exhaustiva

Resumen

Childhood obesity predicts adult obesity and may increase the lifetime risk of adverse health outcomes. Obesity is characterized by oxidative stress that can induce DNA damage; however, studies of childhood and adolescent obesity are scarce. We investigated DNA damage due to obesity in Mexican children using the chromatin dispersion test (CDT). We evaluated DNA damage to peripheral lymphocytes of 32 children grouped according to body mass index as normal weight (controls), overweight and obese groups using guidelines from the Centers for Disease Control (CDC). We found that the greatest DNA damage occurred in cells of obese children compared to normal weight and overweight children. Our findings support preventive action to obviate adverse health outcomes due to obesity.

Idioma originalEnglish
Páginas (desde-hasta)396-400
Número de páginas5
PublicaciónBiotechnic and Histochemistry
Volumen98
N.º6
DOI
EstadoPublished - 2023

Nota bibliográfica

Publisher Copyright:
© 2023 The Biological Stain Commission.

All Science Journal Classification (ASJC) codes

  • Histología
  • Tecnología de laboratorios médicos

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