Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Antonio Martinez-Torteya; Alejandro I. Trejo-Castro; José M. Celaya-Padilla; Jose G. Tamez-Peña

doi:10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Antonio Martinez-Torteya, Alejandro I. Trejo-Castro, José M. Celaya-Padilla, Jose G. Tamez-Peña

Departamento de Ingeniería

Resultado de la investigación

Resumen

An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.

Idioma original	English
Título de la publicación alojada	Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
Editorial	Institute of Electrical and Electronics Engineers (IEEE)
Páginas	199-203
Número de páginas	5
ISBN (versión digital)	9781728146171
ISBN (versión impresa)	9781728146171
DOI	https://doi.org/10.1109/bibe.2019.00043
Estado	Published - oct 2019

Serie de la publicación

Nombre	Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

Nota bibliográfica

Publisher Copyright:
© 2019 IEEE.

All Science Journal Classification (ASJC) codes

Sistemas de información
Ingeniería biomédica
Informática aplicada a la salud

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10.1109/bibe.2019.00043

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Martinez-Torteya, A., Trejo-Castro, A. I., Celaya-Padilla, J. M., & Tamez-Peña, J. G. (2019). Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. En Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 (pp. 199-203). [8941924] (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/bibe.2019.00043

Martinez-Torteya, Antonio ; Trejo-Castro, Alejandro I. ; Celaya-Padilla, José M. ; Tamez-Peña, Jose G. / Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE), 2019. pp. 199-203 (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019).

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title = "Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers",

abstract = "An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.",

author = "Antonio Martinez-Torteya and Trejo-Castro, {Alejandro I.} and Celaya-Padilla, {Jos{\'e} M.} and Tamez-Pe{\~n}a, {Jose G.}",

note = "Funding Information: This work was partially supported by the Consejo Nacional de Ciencia y Tecnologia (CONACYT) and by Universidad de Monterrey through the FFI Grant Funding Information: ACKNOWLEDGMENT This work was partially supported by the Consejo Nacional de Ciencia y Tecnolog{\'i}a (CONACYT) and by Universidad de Monterrey through the FFI Grant. Publisher Copyright: {\textcopyright} 2019 IEEE.",

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Martinez-Torteya, A, Trejo-Castro, AI, Celaya-Padilla, JM & Tamez-Peña, JG 2019, Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. En Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019., 8941924, Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019, Institute of Electrical and Electronics Engineers (IEEE), pp. 199-203. https://doi.org/10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. / Martinez-Torteya, Antonio; Trejo-Castro, Alejandro I.; Celaya-Padilla, José M.; Tamez-Peña, Jose G.

Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE), 2019. p. 199-203 8941924 (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019).

Resultado de la investigación

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AU - Celaya-Padilla, José M.

AU - Tamez-Peña, Jose G.

N1 - Funding Information: This work was partially supported by the Consejo Nacional de Ciencia y Tecnologia (CONACYT) and by Universidad de Monterrey through the FFI Grant Funding Information: ACKNOWLEDGMENT This work was partially supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) and by Universidad de Monterrey through the FFI Grant. Publisher Copyright: © 2019 IEEE.

PY - 2019/10

Y1 - 2019/10

N2 - An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.

AB - An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.

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M3 - Conference contribution

SN - 9781728146171

T3 - Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

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BT - Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

PB - Institute of Electrical and Electronics Engineers (IEEE)

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Martinez-Torteya A, Trejo-Castro AI, Celaya-Padilla JM, Tamez-Peña JG. Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. En Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE). 2019. p. 199-203. 8941924. (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). https://doi.org/10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Resumen

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All Science Journal Classification (ASJC) codes

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