Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Antonio Martinez-Torteya, Alejandro I. Trejo-Castro, José M. Celaya-Padilla, Jose G. Tamez-Peña

Resultado de la investigación

Resumen

An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.
Idioma originalEnglish
Título de la publicación alojadaProceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
EditorialInstitute of Electrical and Electronics Engineers (IEEE)
Páginas199-203
Número de páginas5
ISBN (versión digital)9781728146171
ISBN (versión impresa)9781728146171
DOI
EstadoPublished - oct 2019

Serie de la publicación

NombreProceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Biomedical Engineering
  • Health Informatics

Huella Profundice en los temas de investigación de 'Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers'. En conjunto forman una huella única.

  • Citar esto

    Martinez-Torteya, A., Trejo-Castro, A. I., Celaya-Padilla, J. M., & Tamez-Peña, J. G. (2019). Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. En Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 (pp. 199-203). [8941924] (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/bibe.2019.00043