Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Antonio Martinez-Torteya; Alejandro I. Trejo-Castro; José M. Celaya-Padilla; Jose G. Tamez-Peña

doi:10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Antonio Martinez-Torteya, Alejandro I. Trejo-Castro, José M. Celaya-Padilla, Jose G. Tamez-Peña

Departamento de Ingeniería

Resultado de la investigación

Resumen

An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.

Idioma original	English
Título de la publicación alojada	Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
Editorial	Institute of Electrical and Electronics Engineers (IEEE)
Páginas	199-203
Número de páginas	5
ISBN (versión digital)	9781728146171
ISBN (versión impresa)	9781728146171
DOI	https://doi.org/10.1109/bibe.2019.00043
Estado	Published - oct 2019

Serie de la publicación

Nombre	Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

All Science Journal Classification (ASJC) codes

Information Systems
Biomedical Engineering
Health Informatics

Acceder al documento

10.1109/bibe.2019.00043

Huella Profundice en los temas de investigación de 'Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers'. En conjunto forman una huella única.

Citar esto

Martinez-Torteya, A., Trejo-Castro, A. I., Celaya-Padilla, J. M., & Tamez-Peña, J. G. (2019). Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. En Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 (pp. 199-203). [8941924] (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/bibe.2019.00043

Martinez-Torteya, Antonio ; Trejo-Castro, Alejandro I. ; Celaya-Padilla, José M. ; Tamez-Peña, Jose G. / Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE), 2019. pp. 199-203 (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019).

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abstract = "An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.",

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Martinez-Torteya, A, Trejo-Castro, AI, Celaya-Padilla, JM & Tamez-Peña, JG 2019, Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. En Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019., 8941924, Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019, Institute of Electrical and Electronics Engineers (IEEE), pp. 199-203. https://doi.org/10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. / Martinez-Torteya, Antonio; Trejo-Castro, Alejandro I.; Celaya-Padilla, José M.; Tamez-Peña, Jose G.

Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE), 2019. p. 199-203 8941924 (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019).

Resultado de la investigación

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Martinez-Torteya A, Trejo-Castro AI, Celaya-Padilla JM, Tamez-Peña JG. Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. En Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE). 2019. p. 199-203. 8941924. (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). https://doi.org/10.1109/bibe.2019.00043