Comparative study of antitumor activity between lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine on human squamous cell carcinoma

Fernando Martínez-Pérez, Claudia María García-Cuellar, Rene Hernandez-Delgadillo, Valentin Zaragoza-Magaña, Yesennia Sánchez-Pérez, Irene Meester, Sergio Eduardo Nakagoshi-Cepeda, Juan Manuel Solís-Soto, María Argelia Akemi Nakagoshi-Cepeda, Shankararaman Chellam, Claudio Cabral-Romero

Resultado de la investigación

Resumen

The objective of this study was to compare the antitumor activity of lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine (CHX) on human squamous cell carcinoma. BisBAL NPs were synthesized by colloidal method and characterized by energy dispersive X-ray spectroscopy in conjunction with scanning electron microscopy (EDS-SEM). The effect of BisBAL NPs and CHX on oral cancer cell line (CAL-27) and nontumor control cell human gingival fibroblasts (HGFs) was determined by MTT cell viability assay. The obtained results showed selective inhibition of CAL-27 cell growth by BisBAL nanoclusters. A 24 h exposition to 25 μM BisBAL NP decreased 91% of CAL-27 cell growth, while nontumor HGFs cells were unaffected by BisBAL NPs showing 90% of cell viability. In contrast, CHX kills both CAL-27 and HGFs with the same efficacy. 25 μM of CHX decreased 97% and 80% of tumor and nontumoral cell growth. BisBAL NP and CHX alter cell permeability suggesting that action mechanism may include loss of cell membrane integrity. Also, CHX and not BisBAL NP presented genotoxicity on genomic DNA of tumor cells. As conclusion, BisBAL NPs have a selective antitumor activity on human squamous cell carcinoma, unlike CHX which was cytotoxic for both tumoral and nontumoral control cells.

Idioma originalEnglish
Número de artículo8148219
PublicaciónJournal of Nanomaterials
Volumen2019
DOI
EstadoPublished - 1 ene 2019

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Huella Profundice en los temas de investigación de 'Comparative study of antitumor activity between lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine on human squamous cell carcinoma'. En conjunto forman una huella única.

  • Citar esto

    Martínez-Pérez, F., García-Cuellar, C. M., Hernandez-Delgadillo, R., Zaragoza-Magaña, V., Sánchez-Pérez, Y., Meester, I., Nakagoshi-Cepeda, S. E., Solís-Soto, J. M., Nakagoshi-Cepeda, M. A. A., Chellam, S., & Cabral-Romero, C. (2019). Comparative study of antitumor activity between lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine on human squamous cell carcinoma. Journal of Nanomaterials, 2019, [8148219]. https://doi.org/10.1155/2019/8148219