TY - JOUR
T1 - Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum
AU - Francisco Islas, José
AU - Quiroz-Reyes, Adriana
AU - Delgado-Gonzalez, Paulina
AU - Franco-Villareal, Hector
AU - Delgado-Gallegos, Juan Luis
AU - Garza-Treviño, Elsa N.
AU - Gonzalez-Villarreal, Carlos
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/8/16
Y1 - 2022/8/16
N2 - Gastrointestinal adenocarcinomas are one of the world’s deadliest cancers. Cancer stem cells and the tissue microenvironment are highly regulated by cell and molecular mechanisms. Cancer stem cells are essential for maintenance and progression and are associated with resistance to conventional treatments. This article reviews the current knowledge of the role of the microenvironment during the primary establishment of gastrointestinal adenocarcinomas in the stomach, colon, and rectum and its relationship with cancer stem cells. We also describe novel developments in cancer therapeutics, such as targeted therapy, and discuss the advantages and disadvantages of different treatments for improving gastrointestinal cancer prognosis.
AB - Gastrointestinal adenocarcinomas are one of the world’s deadliest cancers. Cancer stem cells and the tissue microenvironment are highly regulated by cell and molecular mechanisms. Cancer stem cells are essential for maintenance and progression and are associated with resistance to conventional treatments. This article reviews the current knowledge of the role of the microenvironment during the primary establishment of gastrointestinal adenocarcinomas in the stomach, colon, and rectum and its relationship with cancer stem cells. We also describe novel developments in cancer therapeutics, such as targeted therapy, and discuss the advantages and disadvantages of different treatments for improving gastrointestinal cancer prognosis.
UR - http://dx.doi.org/10.3390/cancers14163948
UR - http://www.scopus.com/inward/record.url?scp=85137352805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137352805&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/96e96f0e-40d1-30cb-91e2-b30ccfea0147/
U2 - 10.3390/cancers14163948
DO - 10.3390/cancers14163948
M3 - Review article
C2 - 36010940
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 16
M1 - 3948
ER -
