Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum

José Francisco Islas, Adriana Quiroz-Reyes, Paulina Delgado-Gonzalez, Hector Franco-Villareal, Juan Luis Delgado-Gallegos, Elsa N. Garza-Treviño, Carlos Gonzalez-Villarreal

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2 Citas (Scopus)

Resumen

Gastrointestinal adenocarcinomas are one of the world’s deadliest cancers. Cancer stem cells and the tissue microenvironment are highly regulated by cell and molecular mechanisms. Cancer stem cells are essential for maintenance and progression and are associated with resistance to conventional treatments. This article reviews the current knowledge of the role of the microenvironment during the primary establishment of gastrointestinal adenocarcinomas in the stomach, colon, and rectum and its relationship with cancer stem cells. We also describe novel developments in cancer therapeutics, such as targeted therapy, and discuss the advantages and disadvantages of different treatments for improving gastrointestinal cancer prognosis.
Idioma originalEnglish
Número de artículo3948
PublicaciónCancers
Volumen14
N.º16
DOI
EstadoPublished - 16 ago 2022

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Publisher Copyright:
© 2022 by the authors.

All Science Journal Classification (ASJC) codes

  • Oncología
  • Investigación sobre el cáncer

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