Antimicrobial activity of essential oils-derived volatile compounds against several nosocomial pathogens including representative multidrug-resistant A. Baumannii clinical isolates

B.A. Alanís-Garza, P. Bocanegra-Ibarias, N.W. de Torres, R. Salazar-Aranda, S. Mendoza-Olazarán, L.A. Pérez-López, S. Flores-Treviño, E. Garza-González

Resultado de la investigaciónrevisión exhaustiva

Resumen

The aim was to evaluate the antimicrobial activity of essential oils-derived volatile compounds against nosocomial pathogens, including representative multidrug-resistant (MDR) Acinetobacter baumannii clinical isolates. Minimum inhibitory dose (MID) values for the compounds were determined by the gaseous contact assay. A. baumannii representative clones were selected by pulsed-field gel electrophoresis. MDR profiles were determined by microdilution assay. Drugresistant genes were detected by PCR. Biofilm production was determined by the crystal violet method. From all tested compounds, carvacrol had markedly lower MIDs (3.89–48.8 mg/L) against A. baumannii than against the other nosocomial MDR pathogens. The lowest MID was detected against three strains, which were obtained from different specimen types, had high drug resistance profiles and showed variable biofilm production. The work herein provides evidence that carvacrol may have therapeutic potential as a treatment for MDR A. baumannii infections.

Idioma originalEnglish
Páginas (desde-hasta)341-346
Número de páginas6
PublicaciónJournal of Essential Oil Research
Volumen30
N.º5
DOI
EstadoPublished - 25 jul 2018
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Huella Profundice en los temas de investigación de 'Antimicrobial activity of essential oils-derived volatile compounds against several nosocomial pathogens including representative multidrug-resistant A. Baumannii clinical isolates'. En conjunto forman una huella única.

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