Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

M.J. Guerrero-Muñoz, D.L. Castillo-Carranza, S. Krishnamurthy, A.A. Paulucci-Holthauzen, U. Sengupta, C.A. Lasagna-Reeves, Y. Ahmad, G.R. Jackson, R. Kayed

Resultado de la investigaciónrevisión exhaustiva

36 Citas (Scopus)

Resumen

Alzheimer's disease is a complex disease characterized by overlapping phenotypes with different neurodegenerative disorders. Oligomers are considered the most toxic species in amyloid pathologies. We examined human AD brain samples using an anti-oligomer antibody generated in our laboratory and detected potential hybrid oligomers composed of amyloid-β, prion protein, α-synuclein, and TDP-43 phosphorylated at serines 409 and 410. These data and in vitro results suggest that Aβ oligomer seeds act as a template for the aggregation of other proteins and generate an overlapping phenotype with other neuronal disorders. Furthermore, these results could explain why anti-amyloid-β therapy has been unsuccessful.

Idioma originalEnglish
Páginas (desde-hasta)14-23
Número de páginas10
PublicaciónNeurobiology of Disease
Volumen71
DOI
EstadoPublished - nov 2014
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Neurología

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