Advances in therapeutics for neurodegenerative tauopathies: Moving toward the specific targeting of the most toxic tau species

J.E. Gerson, D.L. Castillo-Carranza, R. Kayed

Producción científicarevisión exhaustiva

57 Citas (Scopus)

Resumen

Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates - tau oligomers - are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions. (Figure Presented).

Idioma originalEnglish
Páginas (desde-hasta)752-769
Número de páginas18
PublicaciónACS Chemical Neuroscience
Volumen5
N.º9
DOI
EstadoPublished - 17 sept 2014
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Bioquímica
  • Fisiología
  • Neurociencia cognitiva
  • Biología celular

Huella

Profundice en los temas de investigación de 'Advances in therapeutics for neurodegenerative tauopathies: Moving toward the specific targeting of the most toxic tau species'. En conjunto forman una huella única.

Citar esto