ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

Rafael B R Leon-Cachon, Mauricio Salinas-Santander, Daniela Alejandra Aguilar-Tamez, Paola Mariana Valdez-Ortiz, Clara Patricia Ríos-Ibarra, Ana Cecilia Cepeda-Nieto, Victor de Jesús Suárez-Valencia, Jesús Antonio Morlett-Chávez

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Resumen

Background: The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose and fatty acids. However, previous association studies between ADIPOQ genetic variants and metabolic disorders have shown controversial results. In this study, we evaluated the effect of the ADIPOQ-rs2241766 polymorphism on diverse biochemical parameters (i.e., insulin resistance, atherogenic index, overweight and obesity) in an adolescent population from Mexico. Methods: A cross-sectional study with convenience sampling was carried out in 356 adolescents from Northern Mexico. They were classified by sex and BMI-z score. The biochemical parameters were measured from blood samples using conventional methods. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In low and normal weight groups, GG carriers had a significantly higher cholesterol level (P ≤ 0.05) than TG and TT carriers. However, there was no association between ADIPOQ-rs2241766 polymorphism and atherogenic index, overweight, or obesity. Conclusions: Our findings suggest that the cholesterol levels are under the influence of the ADIPOQ-rs2241766 polymorphism in Mexican adolescents and may explain how ADIPOQ variants increase the risk of developing metabolic disorders. Nevertheless, further studies are required to rule out the influence of other genetic and non-genetic factors.

Idioma originalEnglish
Páginas (desde-hasta)146-153
Número de páginas8
PublicaciónJournal of Applied Biomedicine
Volumen20
N.º4
DOI
EstadoPublished - 14 dic 2022

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Publisher Copyright:
© 2022 The Authors. Published by University of South Bohemia in České Budějovice, Faculty of Health and Social Sciences.

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