A new method based on quiet stance baseline is more effective in identifying freezing in Parkinson’s disease

Hiram Cantú*, Julie N. Côté, Julie Nantel

*Autor correspondiente de este trabajo

Producción científicarevisión exhaustiva

1 Cita (Scopus)


Freezing, an episodic movement breakdown that goes from disrupted gait patterns to complete arrest, is a disabling symptom in Parkinson’s disease. Several efforts have been made to objectively identify freezing episodes (FEs), although a standardized methodology to discriminate freezing from normal movement is lacking. Novel mathematical approaches that provide information in the temporal and frequency domains, such as the continuous wavelet transform, have demonstrated promising results detecting freezing, although still with limited effectiveness. We aimed to determine whether a computerized algorithm using the continuous wavelet transform based on baseline (i.e. no movement) rather than on amplitude decrease is more effective detecting freezing. Twenty-six individuals with Parkinson’s disease performed two trials of a repetitive stepping-in-place task while they were filmed by a video camera and tracked by a motion capture system. The number of FEs and their total duration were determined from a visual inspection of the videos and from three different computed algorithms. Differences in the number and total duration of the FEs between the video inspection and each of the three methods were obtained. The accuracy to identify the time of occurrence of a FE by each method was also calculated. A significant effect of Method was found for the number (p = 0.016) and total duration (p = 0.013) of the FEs, with the method based on baseline being the closest one to the values reported from the videos. Moreover, the same method was the most accurate in detecting the time of occurrence, and the one reaching the highest sensitivity (88.2%). Findings suggest that threshold detection methods based on baseline and movement amplitude decreases capture different characteristics of Parkinsonian gait, with the first one being more effective at detecting FEs. Moreover, robust approaches that consider both time and frequency characteristics are more sensitive in identifying freezing.

Idioma originalEnglish
Número de artículoe0207945
Páginas (desde-hasta)e0207945
PublicaciónPLoS One
EstadoPublished - 1 nov 2018

All Science Journal Classification (ASJC) codes

  • Bioquímica, genética y biología molecular (todo)
  • Agricultura y biología (todo)


Profundice en los temas de investigación de 'A new method based on quiet stance baseline is more effective in identifying freezing in Parkinson’s disease'. En conjunto forman una huella única.

Citar esto