A MicroRNA perspective on cardiovascular development and diseases: An update

Jose Francisco Islas, Jorge Eugenio Moreno-Cuevas

Resultado de la investigaciónrevisión exhaustiva

22 Citas (Scopus)

Resumen

In this review, we summarize the latest research pertaining to MicroRNAs (miRs) related to cardiovascular diseases. In today’s molecular age, the key clinical aspects of diagnosing and treating these type of diseases are crucial, and miRs play an important role. Therefore, we have made a thorough analysis discussing the most important candidate protagonists of many pathways relating to such conditions as atherosclerosis, heart failure, myocardial infarction, and congenital heart disorders. We approach miRs initially from the fundamental molecular aspects and look at their role in developmental pathways, as well as regulatory mechanisms dysregulated under specific cardiovascular conditions. By doing so, we can better understand their functional roles. Next, we look at therapeutic aspects, including delivery and inhibition techniques. We conclude that a personal approach for treatment is paramount, and so understanding miRs is strategic for cardiovascular health.

Idioma originalEnglish
Número de artículo2075
PublicaciónInternational Journal of Molecular Sciences
Volumen19
N.º7
DOI
EstadoPublished - 17 jul 2018
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Catálisis
  • Biología molecular
  • Espectroscopia
  • Informática aplicada
  • Química física y teórica
  • Química orgánica
  • Química inorgánica

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