A mathematical model for simulating respiratory control during support ventilation modes

Sebastian Larraza, Nilanjan Dey, Dan S. Karbing, Morten Nygaard, Robert Winding, Stephen E. Rees

Resultado de la investigación

6 Citas (Scopus)

Resumen

Mathematical model simulations may assist in the selection of mechanical ventilator settings. Previously, simulations have been limited to control ventilator modes, as these models lacked representation of respiratory control. This paper presents integration of a chemoreflex respiratory control model with models describing: ventilation and pulmonary gas exchange; oxygenation and acid-base status of blood; circulation; interstitial fluid and tissue buffering; and metabolism. A sensitivity analysis showed that typical response to changing ventilator settings can be described by base excess (BE), production of CO2 (VCO2), and model parameters describing central chemoreceptor behavior. Since BE and VCO2, can be routinely measured, changes in ventilator support may therefore be used to identify patient-specific chemoreceptor drive, enabling patient-specific predictions of the response to changes in mechanical ventilation.

Idioma originalEnglish
Título de la publicación alojada19th IFAC World Congress IFAC 2014, Proceedings
EditoresEdward Boje, Xiaohua Xia
EditorialIFAC Secretariat
Páginas8433-8438
Número de páginas6
ISBN (versión digital)9783902823625
ISBN (versión impresa)9783902823625
DOI
EstadoPublished - 1 ene 2014
Evento19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014 - Cape Town
Duración: 24 ago 201429 ago 2014

Serie de la publicación

NombreIFAC Proceedings Volumes (IFAC-PapersOnline)
Volumen19
ISSN (versión impresa)1474-6670

Conference

Conference19th IFAC World Congress on International Federation of Automatic Control, IFAC 2014
País/TerritorioSouth Africa
CiudadCape Town
Período24/8/1429/8/14

All Science Journal Classification (ASJC) codes

  • Ingeniería de control y sistemas

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