Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

Adriana Sampayo-Reyes, Reyes S. Taméz-Guerra, Mario Bermúdez de León, Javier Vargas-Villarreal, Héctor Gerardo Lozano-Garza, Cristina Rodríguez-Padilla, Constanza Cortés, Ricard Marcos, Alba Hernández

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

© 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.
Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalReproductive Toxicology
DOIs
Publication statusPublished - 1 Dec 2017
Externally publishedYes

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Selenious Acid
Tocopherols
Arsenic
Sodium Selenite
Cricetinae
Fetus
Dietary supplements
Placenta
Fetal Resorption
alpha-Tocopherol
Dynamic mechanical analysis
Fetal Mortality
Metabolites
Drinking Water
Pregnancy Outcome
Biotransformation
Dietary Supplements
Animals
Antioxidants
Health

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Sampayo-Reyes, A., Taméz-Guerra, R. S., Bermúdez de León, M., Vargas-Villarreal, J., Lozano-Garza, H. G., Rodríguez-Padilla, C., ... Hernández, A. (2017). Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. Reproductive Toxicology, 204-211. https://doi.org/10.1016/j.reprotox.2017.10.003
Sampayo-Reyes, Adriana ; Taméz-Guerra, Reyes S. ; Bermúdez de León, Mario ; Vargas-Villarreal, Javier ; Lozano-Garza, Héctor Gerardo ; Rodríguez-Padilla, Cristina ; Cortés, Constanza ; Marcos, Ricard ; Hernández, Alba. / Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. In: Reproductive Toxicology. 2017 ; pp. 204-211.
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abstract = "{\circledC} 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.",
author = "Adriana Sampayo-Reyes and Tam{\'e}z-Guerra, {Reyes S.} and {Berm{\'u}dez de Le{\'o}n}, Mario and Javier Vargas-Villarreal and Lozano-Garza, {H{\'e}ctor Gerardo} and Cristina Rodr{\'i}guez-Padilla and Constanza Cort{\'e}s and Ricard Marcos and Alba Hern{\'a}ndez",
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Sampayo-Reyes, A, Taméz-Guerra, RS, Bermúdez de León, M, Vargas-Villarreal, J, Lozano-Garza, HG, Rodríguez-Padilla, C, Cortés, C, Marcos, R & Hernández, A 2017, 'Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters', Reproductive Toxicology, pp. 204-211. https://doi.org/10.1016/j.reprotox.2017.10.003

Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. / Sampayo-Reyes, Adriana; Taméz-Guerra, Reyes S.; Bermúdez de León, Mario; Vargas-Villarreal, Javier; Lozano-Garza, Héctor Gerardo; Rodríguez-Padilla, Cristina; Cortés, Constanza; Marcos, Ricard; Hernández, Alba.

In: Reproductive Toxicology, 01.12.2017, p. 204-211.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

AU - Sampayo-Reyes, Adriana

AU - Taméz-Guerra, Reyes S.

AU - Bermúdez de León, Mario

AU - Vargas-Villarreal, Javier

AU - Lozano-Garza, Héctor Gerardo

AU - Rodríguez-Padilla, Cristina

AU - Cortés, Constanza

AU - Marcos, Ricard

AU - Hernández, Alba

PY - 2017/12/1

Y1 - 2017/12/1

N2 - © 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

AB - © 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

U2 - 10.1016/j.reprotox.2017.10.003

DO - 10.1016/j.reprotox.2017.10.003

M3 - Article

SP - 204

EP - 211

JO - Reproductigve Toxicoloy

JF - Reproductigve Toxicoloy

SN - 0890-6238

ER -

Sampayo-Reyes A, Taméz-Guerra RS, Bermúdez de León M, Vargas-Villarreal J, Lozano-Garza HG, Rodríguez-Padilla C et al. Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. Reproductive Toxicology. 2017 Dec 1;204-211. https://doi.org/10.1016/j.reprotox.2017.10.003

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