Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

Adriana Sampayo-Reyes; Reyes S. Taméz-Guerra; Mario Bermúdez de León; Javier Vargas-Villarreal; Héctor Gerardo Lozano-Garza; Cristina Rodríguez-Padilla; Constanza Cortés; Ricard Marcos; Alba Hernández

doi:10.1016/j.reprotox.2017.10.003

Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

Adriana Sampayo-Reyes, Reyes S. Taméz-Guerra, Mario Bermúdez de León, Javier Vargas-Villarreal, Héctor Gerardo Lozano-Garza, Cristina Rodríguez-Padilla, Constanza Cortés, Ricard Marcos, Alba Hernández

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

Original language	English
Pages (from-to)	204-211
Number of pages	8
Journal	Reproductive Toxicology
Volume	74
DOIs	https://doi.org/10.1016/j.reprotox.2017.10.003
Publication status	Published - 1 Dec 2017
Externally published	Yes

Bibliographical note

Funding Information:
This investigation has been supported in part by a grant from the Instituto Mexicano de la Seguridad Social ( FIS/IMSS/PROT/G11/956 ), the Facultad de Ciencias Biológicas , Universidad Autónoma de Nuevo León , and the Spanish Ministry of Education and Science ( SAF2008-02933 and SAF2011-23146 ). We would like to thank Dr. Susana Pastor for her advice and help with the statistical analysis.

Publisher Copyright:
© 2017 Elsevier Inc.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

Toxicology

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Sampayo-Reyes, Adriana ; Taméz-Guerra, Reyes S. ; Bermúdez de León, Mario ; Vargas-Villarreal, Javier ; Lozano-Garza, Héctor Gerardo ; Rodríguez-Padilla, Cristina ; Cortés, Constanza ; Marcos, Ricard ; Hernández, Alba. / Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. In: Reproductive Toxicology. 2017 ; Vol. 74. pp. 204-211.

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title = "Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters",

abstract = "Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.",

author = "Adriana Sampayo-Reyes and Tam{\'e}z-Guerra, {Reyes S.} and {Berm{\'u}dez de Le{\'o}n}, Mario and Javier Vargas-Villarreal and Lozano-Garza, {H{\'e}ctor Gerardo} and Cristina Rodr{\'i}guez-Padilla and Constanza Cort{\'e}s and Ricard Marcos and Alba Hern{\'a}ndez",

note = "Funding Information: This investigation has been supported in part by a grant from the Instituto Mexicano de la Seguridad Social ( FIS/IMSS/PROT/G11/956 ), the Facultad de Ciencias Biol{\'o}gicas , Universidad Aut{\'o}noma de Nuevo Le{\'o}n , and the Spanish Ministry of Education and Science ( SAF2008-02933 and SAF2011-23146 ). We would like to thank Dr. Susana Pastor for her advice and help with the statistical analysis. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2017",

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doi = "10.1016/j.reprotox.2017.10.003",

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Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. / Sampayo-Reyes, Adriana; Taméz-Guerra, Reyes S.; Bermúdez de León, Mario; Vargas-Villarreal, Javier; Lozano-Garza, Héctor Gerardo; Rodríguez-Padilla, Cristina; Cortés, Constanza; Marcos, Ricard; Hernández, Alba.

In: Reproductive Toxicology, Vol. 74, 01.12.2017, p. 204-211.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters

AU - Sampayo-Reyes, Adriana

AU - Taméz-Guerra, Reyes S.

AU - Bermúdez de León, Mario

AU - Vargas-Villarreal, Javier

AU - Lozano-Garza, Héctor Gerardo

AU - Rodríguez-Padilla, Cristina

AU - Cortés, Constanza

AU - Marcos, Ricard

AU - Hernández, Alba

N1 - Funding Information: This investigation has been supported in part by a grant from the Instituto Mexicano de la Seguridad Social ( FIS/IMSS/PROT/G11/956 ), the Facultad de Ciencias Biológicas , Universidad Autónoma de Nuevo León , and the Spanish Ministry of Education and Science ( SAF2008-02933 and SAF2011-23146 ). We would like to thank Dr. Susana Pastor for her advice and help with the statistical analysis. Publisher Copyright: © 2017 Elsevier Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

AB - Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.

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