Abstract
Original language | English |
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Pages (from-to) | 204-211 |
Number of pages | 8 |
Journal | Reproductive Toxicology |
DOIs | |
Publication status | Published - 1 Dec 2017 |
Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Toxicology
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Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. / Sampayo-Reyes, Adriana; Taméz-Guerra, Reyes S.; Bermúdez de León, Mario; Vargas-Villarreal, Javier; Lozano-Garza, Héctor Gerardo; Rodríguez-Padilla, Cristina; Cortés, Constanza; Marcos, Ricard; Hernández, Alba.
In: Reproductive Toxicology, 01.12.2017, p. 204-211.Research output: Contribution to journal › Article
TY - JOUR
T1 - Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters
AU - Sampayo-Reyes, Adriana
AU - Taméz-Guerra, Reyes S.
AU - Bermúdez de León, Mario
AU - Vargas-Villarreal, Javier
AU - Lozano-Garza, Héctor Gerardo
AU - Rodríguez-Padilla, Cristina
AU - Cortés, Constanza
AU - Marcos, Ricard
AU - Hernández, Alba
PY - 2017/12/1
Y1 - 2017/12/1
N2 - © 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.
AB - © 2017 Elsevier Inc. Human studies suggest that in utero exposure to arsenic results in adverse pregnancy outcomes. The use of dietary supplements, such as sodium selenite (SS) or α-tocopherol succinate (α-TOS), is a reasonable approach to ameliorate such health effects. Sodium arsenite at 100 ppm was administered via drinking water to female hamsters from gestational days 1 or 8 to the time of delivery. Viable fetuses, fetal resorptions and non-viable fetuses were recorded during and after pregnancy and total arsenic and its metabolites were characterized in pregnant animals, placentas and fetuses. Arsenic was found to accumulate in the placenta and fetus, increasing fetal mortality, non-viable fetuses and resorptions. Co-administration of SS and α-TOS significantly reduced the observed teratogenic effects. SS influenced arsenic biotransformation by reducing the MMA/InAs index and increasing the DMA/MMA, whereas α-TOS more likely exerts its protective effect through its potent antioxidant activity.
U2 - 10.1016/j.reprotox.2017.10.003
DO - 10.1016/j.reprotox.2017.10.003
M3 - Article
SP - 204
EP - 211
JO - Reproductigve Toxicoloy
JF - Reproductigve Toxicoloy
SN - 0890-6238
ER -