The effect of body composition and serum inflammatory markers on the functional muscle-bone unit in premenopausal women

S. M. Mueller, I. Herter-Aeberli, A. C. Cepeda-Lopez, M. Flück, H. H. Jung, M. Toigo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background/Objectives:A number of recent studies dealing with the relationship between the effects of high body mass (BM) and fat mass (FM) on bone mass and strength exhibit a range of contrasting variations in their findings. These diverse findings have led to an ongoing controversy as to whether high BM and FM positively or negatively affect bone mass and strength. Excessive FM and the associated low-grade inflammation might overturn the higher mechanical stimulus arising from a higher BM. Therefore, we aimed at quantifying the functional muscle-bone unit in premenopausal women with markedly diverging body composition.Subjects/Methods:Sixty-four young women with BMs ranging from 50 to 113 kg and body fat percentages between 20.7% and 51.8% underwent jumping mechanography and peripheral quantitative computed tomography measurements. Maximum voluntary ground reaction force during multiple one-legged hopping (F m1LH), as well as bone characteristics at 4, 14 and 38% of tibia length, were determined. Body composition was assessed by dual-energy X-ray absorptiometry, and serum inflammatory markers were analyzed from blood samples.Results:F m1LH predicted volumetric bone mineral content at the 14% site by 48.7%. Women with high body fat percentage had significantly higher F m1LH, significantly lower relative bone mass, relative bone strength and relative bone area, as well as higher serum inflammatory markers in comparison to women with lower body fat percentage.Conclusions:In conclusion, high body fat percentage was associated with lower relative bone mass and strength despite normal habitual muscle force in premenopausal women, indicating that high body fat percentage compromised the functional muscle-bone unit in these individuals.
Original languageEnglish
Pages (from-to)1203-1206
Number of pages4
JournalInternational Journal of Obesity
DOIs
Publication statusPublished - 1 Aug 2017

Fingerprint

Body Composition
Biomarkers
Bone and Bones
Muscles
Adipose Tissue
Fats
Photon Absorptiometry
Tibia
Bone Density
Tomography
Inflammation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

@article{eb191a138f704acdb2ddad5ad14b7028,
title = "The effect of body composition and serum inflammatory markers on the functional muscle-bone unit in premenopausal women",
abstract = "{\circledC} 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background/Objectives:A number of recent studies dealing with the relationship between the effects of high body mass (BM) and fat mass (FM) on bone mass and strength exhibit a range of contrasting variations in their findings. These diverse findings have led to an ongoing controversy as to whether high BM and FM positively or negatively affect bone mass and strength. Excessive FM and the associated low-grade inflammation might overturn the higher mechanical stimulus arising from a higher BM. Therefore, we aimed at quantifying the functional muscle-bone unit in premenopausal women with markedly diverging body composition.Subjects/Methods:Sixty-four young women with BMs ranging from 50 to 113 kg and body fat percentages between 20.7{\%} and 51.8{\%} underwent jumping mechanography and peripheral quantitative computed tomography measurements. Maximum voluntary ground reaction force during multiple one-legged hopping (F m1LH), as well as bone characteristics at 4, 14 and 38{\%} of tibia length, were determined. Body composition was assessed by dual-energy X-ray absorptiometry, and serum inflammatory markers were analyzed from blood samples.Results:F m1LH predicted volumetric bone mineral content at the 14{\%} site by 48.7{\%}. Women with high body fat percentage had significantly higher F m1LH, significantly lower relative bone mass, relative bone strength and relative bone area, as well as higher serum inflammatory markers in comparison to women with lower body fat percentage.Conclusions:In conclusion, high body fat percentage was associated with lower relative bone mass and strength despite normal habitual muscle force in premenopausal women, indicating that high body fat percentage compromised the functional muscle-bone unit in these individuals.",
author = "Mueller, {S. M.} and I. Herter-Aeberli and Cepeda-Lopez, {A. C.} and M. Fl{\"u}ck and Jung, {H. H.} and M. Toigo",
year = "2017",
month = "8",
day = "1",
doi = "10.1038/ijo.2017.100",
language = "English",
pages = "1203--1206",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",

}

The effect of body composition and serum inflammatory markers on the functional muscle-bone unit in premenopausal women. / Mueller, S. M.; Herter-Aeberli, I.; Cepeda-Lopez, A. C.; Flück, M.; Jung, H. H.; Toigo, M.

In: International Journal of Obesity, 01.08.2017, p. 1203-1206.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of body composition and serum inflammatory markers on the functional muscle-bone unit in premenopausal women

AU - Mueller, S. M.

AU - Herter-Aeberli, I.

AU - Cepeda-Lopez, A. C.

AU - Flück, M.

AU - Jung, H. H.

AU - Toigo, M.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background/Objectives:A number of recent studies dealing with the relationship between the effects of high body mass (BM) and fat mass (FM) on bone mass and strength exhibit a range of contrasting variations in their findings. These diverse findings have led to an ongoing controversy as to whether high BM and FM positively or negatively affect bone mass and strength. Excessive FM and the associated low-grade inflammation might overturn the higher mechanical stimulus arising from a higher BM. Therefore, we aimed at quantifying the functional muscle-bone unit in premenopausal women with markedly diverging body composition.Subjects/Methods:Sixty-four young women with BMs ranging from 50 to 113 kg and body fat percentages between 20.7% and 51.8% underwent jumping mechanography and peripheral quantitative computed tomography measurements. Maximum voluntary ground reaction force during multiple one-legged hopping (F m1LH), as well as bone characteristics at 4, 14 and 38% of tibia length, were determined. Body composition was assessed by dual-energy X-ray absorptiometry, and serum inflammatory markers were analyzed from blood samples.Results:F m1LH predicted volumetric bone mineral content at the 14% site by 48.7%. Women with high body fat percentage had significantly higher F m1LH, significantly lower relative bone mass, relative bone strength and relative bone area, as well as higher serum inflammatory markers in comparison to women with lower body fat percentage.Conclusions:In conclusion, high body fat percentage was associated with lower relative bone mass and strength despite normal habitual muscle force in premenopausal women, indicating that high body fat percentage compromised the functional muscle-bone unit in these individuals.

AB - © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background/Objectives:A number of recent studies dealing with the relationship between the effects of high body mass (BM) and fat mass (FM) on bone mass and strength exhibit a range of contrasting variations in their findings. These diverse findings have led to an ongoing controversy as to whether high BM and FM positively or negatively affect bone mass and strength. Excessive FM and the associated low-grade inflammation might overturn the higher mechanical stimulus arising from a higher BM. Therefore, we aimed at quantifying the functional muscle-bone unit in premenopausal women with markedly diverging body composition.Subjects/Methods:Sixty-four young women with BMs ranging from 50 to 113 kg and body fat percentages between 20.7% and 51.8% underwent jumping mechanography and peripheral quantitative computed tomography measurements. Maximum voluntary ground reaction force during multiple one-legged hopping (F m1LH), as well as bone characteristics at 4, 14 and 38% of tibia length, were determined. Body composition was assessed by dual-energy X-ray absorptiometry, and serum inflammatory markers were analyzed from blood samples.Results:F m1LH predicted volumetric bone mineral content at the 14% site by 48.7%. Women with high body fat percentage had significantly higher F m1LH, significantly lower relative bone mass, relative bone strength and relative bone area, as well as higher serum inflammatory markers in comparison to women with lower body fat percentage.Conclusions:In conclusion, high body fat percentage was associated with lower relative bone mass and strength despite normal habitual muscle force in premenopausal women, indicating that high body fat percentage compromised the functional muscle-bone unit in these individuals.

U2 - 10.1038/ijo.2017.100

DO - 10.1038/ijo.2017.100

M3 - Article

SP - 1203

EP - 1206

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

ER -