Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes

Antonio Sánchez-Fernández, Laura Peña-Parás, Román Vidaltamayo, Rodrigo Cué-Sampedro, Ana Mendoza-Martínez, Viviana C. Zomosa-Signoret, Ana M. Rivas-Estilla, Paulina Riojas

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Halloysite is an aluminosilicate clay that has been widely used for controlled drug delivery, immobilization of enzymes, and for the capture of circulating tumor cells (CTCs). Surface modification of halloysite by organosilanes has been explored to improve their properties. In this study halloysite clay nanotubes (HNTs) were functionalized by two different organosilanes: Trimethoxy(propyl)silane (TMPS), and Triethoxy(octyl)silane (EOS). Untreated and modified samples were characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermogravimetrical analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). Results showed a strong interaction of organosilanes with the chemical groups present in HNTs. Biocompatibility and cytotoxicity of these nanomaterials were determined using C6 rat glioblastoma cells. Our results indicate that prior to functionalization, HNTs show a high biocompatibility and low cytotoxicity. However, HNTs functionalized with EOS and TMPS showed high cytotoxicity by inducing apoptosis. These results allow the identification of potential applications in biomedical areas for HNTs.
Original languageEnglish
Pages (from-to)7770-7780
Number of pages11
Issue number12
Publication statusPublished - 1 Jan 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science


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