Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes

Antonio Sánchez-Fernández, Laura Peña-Parás, Román Vidaltamayo, Rodrigo Cué-Sampedro, Ana Mendoza-Martínez, Viviana C. Zomosa-Signoret, Ana M. Rivas-Estilla, Paulina Riojas

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Halloysite is an aluminosilicate clay that has been widely used for controlled drug delivery, immobilization of enzymes, and for the capture of circulating tumor cells (CTCs). Surface modification of halloysite by organosilanes has been explored to improve their properties. In this study halloysite clay nanotubes (HNTs) were functionalized by two different organosilanes: Trimethoxy(propyl)silane (TMPS), and Triethoxy(octyl)silane (EOS). Untreated and modified samples were characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermogravimetrical analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). Results showed a strong interaction of organosilanes with the chemical groups present in HNTs. Biocompatibility and cytotoxicity of these nanomaterials were determined using C6 rat glioblastoma cells. Our results indicate that prior to functionalization, HNTs show a high biocompatibility and low cytotoxicity. However, HNTs functionalized with EOS and TMPS showed high cytotoxicity by inducing apoptosis. These results allow the identification of potential applications in biomedical areas for HNTs.
Original languageEnglish
Pages (from-to)7770-7780
Number of pages11
JournalMaterials
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

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Biocompatible Materials
Cytotoxicity
Biomaterials
Nanotubes
Clay
Silanes
Biocompatibility
Controlled drug delivery
Aluminosilicates
Cell death
Nanostructured materials
X ray diffraction analysis
Fourier transform infrared spectroscopy
Surface treatment
clay
Rats
Tumors
Enzymes
Cells
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Sánchez-Fernández, Antonio ; Peña-Parás, Laura ; Vidaltamayo, Román ; Cué-Sampedro, Rodrigo ; Mendoza-Martínez, Ana ; Zomosa-Signoret, Viviana C. ; Rivas-Estilla, Ana M. ; Riojas, Paulina. / Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes. In: Materials. 2014 ; pp. 7770-7780.
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abstract = "Halloysite is an aluminosilicate clay that has been widely used for controlled drug delivery, immobilization of enzymes, and for the capture of circulating tumor cells (CTCs). Surface modification of halloysite by organosilanes has been explored to improve their properties. In this study halloysite clay nanotubes (HNTs) were functionalized by two different organosilanes: Trimethoxy(propyl)silane (TMPS), and Triethoxy(octyl)silane (EOS). Untreated and modified samples were characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermogravimetrical analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). Results showed a strong interaction of organosilanes with the chemical groups present in HNTs. Biocompatibility and cytotoxicity of these nanomaterials were determined using C6 rat glioblastoma cells. Our results indicate that prior to functionalization, HNTs show a high biocompatibility and low cytotoxicity. However, HNTs functionalized with EOS and TMPS showed high cytotoxicity by inducing apoptosis. These results allow the identification of potential applications in biomedical areas for HNTs.",
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Sánchez-Fernández, A, Peña-Parás, L, Vidaltamayo, R, Cué-Sampedro, R, Mendoza-Martínez, A, Zomosa-Signoret, VC, Rivas-Estilla, AM & Riojas, P 2014, 'Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes', Materials, pp. 7770-7780. https://doi.org/10.3390/ma7127770

Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes. / Sánchez-Fernández, Antonio; Peña-Parás, Laura; Vidaltamayo, Román; Cué-Sampedro, Rodrigo; Mendoza-Martínez, Ana; Zomosa-Signoret, Viviana C.; Rivas-Estilla, Ana M.; Riojas, Paulina.

In: Materials, 01.01.2014, p. 7770-7780.

Research output: Contribution to journalArticle

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AU - Sánchez-Fernández, Antonio

AU - Peña-Parás, Laura

AU - Vidaltamayo, Román

AU - Cué-Sampedro, Rodrigo

AU - Mendoza-Martínez, Ana

AU - Zomosa-Signoret, Viviana C.

AU - Rivas-Estilla, Ana M.

AU - Riojas, Paulina

PY - 2014/1/1

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