Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)

Jose Leon-Carrion, Umberto Leon-Dominguez, Luca Pollonini, Meng Hung Wu, Richard E. Frye, Maria Rosario Dominguez-Morales, George Zouridakis

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Survivors of traumatic brain injury (TBI) often suffer disorders of consciousness as a result of a breakdown in cortical connectivity. However, little is known about the neural discharges and cortical areas working in synchrony to generate consciousness in these patients. In this study, we analyzed cortical connectivity in patients with severe neurocognitive disorder (SND) and in the minimally conscious state (MCS). We found two synchronized networks subserving consciousness; one retrolandic (cognitive network) and the other frontal (executive control network). The synchrony between these networks is severely disrupted in patients in the MCS as compared to those with better levels of consciousness and a preserved state of alertness (SND). The executive control network could facilitate the synchronization and coherence of large populations of distant cortical neurons using high frequency oscillations on a precise temporal scale. Consciousness is altered or disappears after losing synchrony and coherence. We suggest that the synchrony between anterior and retrolandic regions is essential to awareness, and that a functioning frontal lobe is a surrogate marker for preserved consciousness. This article is part of a Special Issue entitled: Brain Integration. © 2012 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)22-30
Number of pages9
JournalBrain Research
DOIs
Publication statusPublished - 2 Oct 2012
Externally publishedYes

Fingerprint

Consciousness
Persistent Vegetative State
Executive Function
Consciousness Disorders
Frontal Lobe
Survivors
Biomarkers
Traumatic Brain Injury
Neurons
Brain
Population
Neurocognitive Disorders

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Leon-Carrion, Jose ; Leon-Dominguez, Umberto ; Pollonini, Luca ; Wu, Meng Hung ; Frye, Richard E. ; Dominguez-Morales, Maria Rosario ; Zouridakis, George. / Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI). In: Brain Research. 2012 ; pp. 22-30.
@article{d95831e98a024703b8e85f5e2272303f,
title = "Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)",
abstract = "Survivors of traumatic brain injury (TBI) often suffer disorders of consciousness as a result of a breakdown in cortical connectivity. However, little is known about the neural discharges and cortical areas working in synchrony to generate consciousness in these patients. In this study, we analyzed cortical connectivity in patients with severe neurocognitive disorder (SND) and in the minimally conscious state (MCS). We found two synchronized networks subserving consciousness; one retrolandic (cognitive network) and the other frontal (executive control network). The synchrony between these networks is severely disrupted in patients in the MCS as compared to those with better levels of consciousness and a preserved state of alertness (SND). The executive control network could facilitate the synchronization and coherence of large populations of distant cortical neurons using high frequency oscillations on a precise temporal scale. Consciousness is altered or disappears after losing synchrony and coherence. We suggest that the synchrony between anterior and retrolandic regions is essential to awareness, and that a functioning frontal lobe is a surrogate marker for preserved consciousness. This article is part of a Special Issue entitled: Brain Integration. {\circledC} 2012 Elsevier B.V. All rights reserved.",
author = "Jose Leon-Carrion and Umberto Leon-Dominguez and Luca Pollonini and Wu, {Meng Hung} and Frye, {Richard E.} and Dominguez-Morales, {Maria Rosario} and George Zouridakis",
year = "2012",
month = "10",
day = "2",
doi = "10.1016/j.brainres.2012.03.055",
language = "English",
pages = "22--30",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI). / Leon-Carrion, Jose; Leon-Dominguez, Umberto; Pollonini, Luca; Wu, Meng Hung; Frye, Richard E.; Dominguez-Morales, Maria Rosario; Zouridakis, George.

In: Brain Research, 02.10.2012, p. 22-30.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synchronization between the anterior and posterior cortex determines consciousness level in patients with traumatic brain injury (TBI)

AU - Leon-Carrion, Jose

AU - Leon-Dominguez, Umberto

AU - Pollonini, Luca

AU - Wu, Meng Hung

AU - Frye, Richard E.

AU - Dominguez-Morales, Maria Rosario

AU - Zouridakis, George

PY - 2012/10/2

Y1 - 2012/10/2

N2 - Survivors of traumatic brain injury (TBI) often suffer disorders of consciousness as a result of a breakdown in cortical connectivity. However, little is known about the neural discharges and cortical areas working in synchrony to generate consciousness in these patients. In this study, we analyzed cortical connectivity in patients with severe neurocognitive disorder (SND) and in the minimally conscious state (MCS). We found two synchronized networks subserving consciousness; one retrolandic (cognitive network) and the other frontal (executive control network). The synchrony between these networks is severely disrupted in patients in the MCS as compared to those with better levels of consciousness and a preserved state of alertness (SND). The executive control network could facilitate the synchronization and coherence of large populations of distant cortical neurons using high frequency oscillations on a precise temporal scale. Consciousness is altered or disappears after losing synchrony and coherence. We suggest that the synchrony between anterior and retrolandic regions is essential to awareness, and that a functioning frontal lobe is a surrogate marker for preserved consciousness. This article is part of a Special Issue entitled: Brain Integration. © 2012 Elsevier B.V. All rights reserved.

AB - Survivors of traumatic brain injury (TBI) often suffer disorders of consciousness as a result of a breakdown in cortical connectivity. However, little is known about the neural discharges and cortical areas working in synchrony to generate consciousness in these patients. In this study, we analyzed cortical connectivity in patients with severe neurocognitive disorder (SND) and in the minimally conscious state (MCS). We found two synchronized networks subserving consciousness; one retrolandic (cognitive network) and the other frontal (executive control network). The synchrony between these networks is severely disrupted in patients in the MCS as compared to those with better levels of consciousness and a preserved state of alertness (SND). The executive control network could facilitate the synchronization and coherence of large populations of distant cortical neurons using high frequency oscillations on a precise temporal scale. Consciousness is altered or disappears after losing synchrony and coherence. We suggest that the synchrony between anterior and retrolandic regions is essential to awareness, and that a functioning frontal lobe is a surrogate marker for preserved consciousness. This article is part of a Special Issue entitled: Brain Integration. © 2012 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.brainres.2012.03.055

DO - 10.1016/j.brainres.2012.03.055

M3 - Article

SP - 22

EP - 30

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -