Survival and clinical features in Hispanic amyotrophic lateral sclerosis patients

Héctor R. Martínez, Juan Francisco Molina-López, Leonel Cantú-Martínez, María Teresa González-Garza, Jorge E. Moreno-Cuevas, Patricio Couret-Alcaraz, Sergio A. Treviño, Yenny Webb-Vargas, Enrique Caro, Alfonso Gil-Valadez, Jesús Santos-Guzmán, Martin Hernandez-Torre

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The demography, survival, and motor phenotypes of amyotrophic lateral sclerosis (ALS) patients have been rarely described in Hispanic countries. The clinical characteristics and survival of a series of Mexican ALS patients are described. Mexican patients with definite ALS were included in a five-year retrospective longitudinal study. Their demographic and clinical features, cumulative survival rates, and independent predictive factors for survival were analysed. Sixty-one definite ALS patients were included. The median follow-up period was 35 months (range 12-108 months). Males were predominant (1.8: 1), the mean age at onset was 47.5 ± 10.5 years, and the median interval from onset to diagnosis was 12 months. Spinal onset occurred in 66% of patients. Upper motor neuron phenotype was predominant in 53% of patients. The overall mean survival from onset was 68.6 months, and from diagnosis was 57.8 months. Longer survival was determined in patients aged ≤ 40 years (54.7 months) compared with other age groups (p = 0.006). In conclusion, the clinical heterogeneity, male predominance, and survival rates in our sample are consistent with those of other studies. Patients in this series had a younger age at onset and a clear trend toward longer survival compared with those of other population studies.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalAmyotrophic Lateral Sclerosis
Volume12
Issue number3
DOIs
Publication statusPublished - 1 May 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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