Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method

Janett Carmen Luzmila Riega-Torres, Antonio Jaime Villarreal-Gonzalez, Luis Ángel Ceceñas-Falcon, Julio Cesar Salas-Alanis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

© 2016, Academia Nacional de Medicina. All rights reserved. Sjögren’s syndrome is a chronic autoimmune disease whose main clinical manifestation is oral dryness (xerostomia) and ocular dryness (xerophthalmia). It is characterized by progressive mononuclear infiltration of the exocrine glands and can affect a variety of organ systems. The prevalence of primary Sjögren’s syndrome varies from 0.01 up to 4.8[%]; this variability reflects differences in definition, application of diagnostic criteria, and geographic differences in age groups. The etiology of primary Sjögren’s syndrome is unknown, but the interaction between genetic and environmental factors (viruses, hormones, vitamins, stress) is important. There are few reported cases of concordance in monozygotic twins, and it is common for patients with primary Sjögren’s syndrome to have relatives with other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, thyroid disease, psoriasis, and multiple sclerosis. Among the most common findings ishypergammaglobulinemia. Elevated levels of ?-globulins contain autoantibodies directed against nonspecific antigens such as rheumatoid factor, antinuclear antibodies, and cellular antigens SS-A/Ro and SS-B/La. Regarding diagnosis, there have been 11 different published criteria for Sjögren’s syndrome since 1965; none have been approved by the American College of Rheumatology or the European League Against Rheumatism. The current criteria were published in 2012 jointly with the progressive advance in the knowledge of the human salivary proteome that has gained wide acceptance in Sjögren’s syndrome, with the possibility of using saliva as a useful tool in both diagnosis and prognosis in this field because the analysis of salivary proteins may reflect the state of locally underlying disease of the salivary glands, which are the target organs in this disease.
Original languageEnglish
Pages (from-to)371-380
Number of pages10
JournalGaceta Medica de Mexico
Publication statusPublished - 1 May 2016
Externally publishedYes

Fingerprint

Saliva
Xerostomia
Autoimmune Diseases
Salivary Gland Diseases
Xerophthalmia
Exocrine Glands
Salivary Proteins and Peptides
Antigens
Monozygotic Twins
Rheumatoid Factor
Antinuclear Antibodies
Thyroid Diseases
Globulins
Proteome
Psoriasis
Vitamins
Systemic Lupus Erythematosus
Autoantibodies
Multiple Sclerosis
Rheumatoid Arthritis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Riega-Torres, J. C. L., Villarreal-Gonzalez, A. J., Ceceñas-Falcon, L. Á., & Salas-Alanis, J. C. (2016). Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method. Gaceta Medica de Mexico, 371-380.
Riega-Torres, Janett Carmen Luzmila ; Villarreal-Gonzalez, Antonio Jaime ; Ceceñas-Falcon, Luis Ángel ; Salas-Alanis, Julio Cesar. / Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method. In: Gaceta Medica de Mexico. 2016 ; pp. 371-380.
@article{8ee01e3d35564ea08560ae32dabb6e73,
title = "Sj{\"o}gren's syndrome (SS), a review of the subject and saliva as a diagnostic method",
abstract = "{\circledC} 2016, Academia Nacional de Medicina. All rights reserved. Sj{\"o}gren’s syndrome is a chronic autoimmune disease whose main clinical manifestation is oral dryness (xerostomia) and ocular dryness (xerophthalmia). It is characterized by progressive mononuclear infiltration of the exocrine glands and can affect a variety of organ systems. The prevalence of primary Sj{\"o}gren’s syndrome varies from 0.01 up to 4.8[{\%}]; this variability reflects differences in definition, application of diagnostic criteria, and geographic differences in age groups. The etiology of primary Sj{\"o}gren’s syndrome is unknown, but the interaction between genetic and environmental factors (viruses, hormones, vitamins, stress) is important. There are few reported cases of concordance in monozygotic twins, and it is common for patients with primary Sj{\"o}gren’s syndrome to have relatives with other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, thyroid disease, psoriasis, and multiple sclerosis. Among the most common findings ishypergammaglobulinemia. Elevated levels of ?-globulins contain autoantibodies directed against nonspecific antigens such as rheumatoid factor, antinuclear antibodies, and cellular antigens SS-A/Ro and SS-B/La. Regarding diagnosis, there have been 11 different published criteria for Sj{\"o}gren’s syndrome since 1965; none have been approved by the American College of Rheumatology or the European League Against Rheumatism. The current criteria were published in 2012 jointly with the progressive advance in the knowledge of the human salivary proteome that has gained wide acceptance in Sj{\"o}gren’s syndrome, with the possibility of using saliva as a useful tool in both diagnosis and prognosis in this field because the analysis of salivary proteins may reflect the state of locally underlying disease of the salivary glands, which are the target organs in this disease.",
author = "Riega-Torres, {Janett Carmen Luzmila} and Villarreal-Gonzalez, {Antonio Jaime} and Cece{\~n}as-Falcon, {Luis {\'A}ngel} and Salas-Alanis, {Julio Cesar}",
year = "2016",
month = "5",
day = "1",
language = "English",
pages = "371--380",
journal = "Gaceta Medica de Mexico",
issn = "0016-3813",
publisher = "Academia Nacional de Medicina",

}

Riega-Torres, JCL, Villarreal-Gonzalez, AJ, Ceceñas-Falcon, LÁ & Salas-Alanis, JC 2016, 'Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method', Gaceta Medica de Mexico, pp. 371-380.

Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method. / Riega-Torres, Janett Carmen Luzmila; Villarreal-Gonzalez, Antonio Jaime; Ceceñas-Falcon, Luis Ángel; Salas-Alanis, Julio Cesar.

In: Gaceta Medica de Mexico, 01.05.2016, p. 371-380.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method

AU - Riega-Torres, Janett Carmen Luzmila

AU - Villarreal-Gonzalez, Antonio Jaime

AU - Ceceñas-Falcon, Luis Ángel

AU - Salas-Alanis, Julio Cesar

PY - 2016/5/1

Y1 - 2016/5/1

N2 - © 2016, Academia Nacional de Medicina. All rights reserved. Sjögren’s syndrome is a chronic autoimmune disease whose main clinical manifestation is oral dryness (xerostomia) and ocular dryness (xerophthalmia). It is characterized by progressive mononuclear infiltration of the exocrine glands and can affect a variety of organ systems. The prevalence of primary Sjögren’s syndrome varies from 0.01 up to 4.8[%]; this variability reflects differences in definition, application of diagnostic criteria, and geographic differences in age groups. The etiology of primary Sjögren’s syndrome is unknown, but the interaction between genetic and environmental factors (viruses, hormones, vitamins, stress) is important. There are few reported cases of concordance in monozygotic twins, and it is common for patients with primary Sjögren’s syndrome to have relatives with other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, thyroid disease, psoriasis, and multiple sclerosis. Among the most common findings ishypergammaglobulinemia. Elevated levels of ?-globulins contain autoantibodies directed against nonspecific antigens such as rheumatoid factor, antinuclear antibodies, and cellular antigens SS-A/Ro and SS-B/La. Regarding diagnosis, there have been 11 different published criteria for Sjögren’s syndrome since 1965; none have been approved by the American College of Rheumatology or the European League Against Rheumatism. The current criteria were published in 2012 jointly with the progressive advance in the knowledge of the human salivary proteome that has gained wide acceptance in Sjögren’s syndrome, with the possibility of using saliva as a useful tool in both diagnosis and prognosis in this field because the analysis of salivary proteins may reflect the state of locally underlying disease of the salivary glands, which are the target organs in this disease.

AB - © 2016, Academia Nacional de Medicina. All rights reserved. Sjögren’s syndrome is a chronic autoimmune disease whose main clinical manifestation is oral dryness (xerostomia) and ocular dryness (xerophthalmia). It is characterized by progressive mononuclear infiltration of the exocrine glands and can affect a variety of organ systems. The prevalence of primary Sjögren’s syndrome varies from 0.01 up to 4.8[%]; this variability reflects differences in definition, application of diagnostic criteria, and geographic differences in age groups. The etiology of primary Sjögren’s syndrome is unknown, but the interaction between genetic and environmental factors (viruses, hormones, vitamins, stress) is important. There are few reported cases of concordance in monozygotic twins, and it is common for patients with primary Sjögren’s syndrome to have relatives with other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, thyroid disease, psoriasis, and multiple sclerosis. Among the most common findings ishypergammaglobulinemia. Elevated levels of ?-globulins contain autoantibodies directed against nonspecific antigens such as rheumatoid factor, antinuclear antibodies, and cellular antigens SS-A/Ro and SS-B/La. Regarding diagnosis, there have been 11 different published criteria for Sjögren’s syndrome since 1965; none have been approved by the American College of Rheumatology or the European League Against Rheumatism. The current criteria were published in 2012 jointly with the progressive advance in the knowledge of the human salivary proteome that has gained wide acceptance in Sjögren’s syndrome, with the possibility of using saliva as a useful tool in both diagnosis and prognosis in this field because the analysis of salivary proteins may reflect the state of locally underlying disease of the salivary glands, which are the target organs in this disease.

M3 - Article

SP - 371

EP - 380

JO - Gaceta Medica de Mexico

JF - Gaceta Medica de Mexico

SN - 0016-3813

ER -

Riega-Torres JCL, Villarreal-Gonzalez AJ, Ceceñas-Falcon LÁ, Salas-Alanis JC. Sjögren's syndrome (SS), a review of the subject and saliva as a diagnostic method. Gaceta Medica de Mexico. 2016 May 1;371-380.