Retnla down-regulation and IL-13-rich environment correlate with inflammation severity in experimental actinomycetoma by Nocardia brasiliensis

Irene Meester, Adrián G. Rosas-Taraco, Mario C. Salinas-Carmona

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Nocardia brasiliensis (Nb) is a facultative intracellular pathogen that may cause actinomycetoma when immune response is unable to control the pathogenic invasion. We used comparative real-time PCR to evaluate the expression level of molecules indicative of either classical or alternative activation of macrophages, as well as of cytokines involved in macrophage polarization, during the experimental infection in BALB/c mice. We found induction or increased expression of the proinflammatory markers csf2/GM-CSF, interferon-gamma, and nos2/iNOS. The expression of Ym1 and IL-13, which are usually related with alternative activation of macrophage, was also increased. However, retnla/FIZZ1 expression decreased sharply during the infection. We concluded that Nb infection induces both a proinflammatory and anti-inflammatory environment, in which there is a strong inverse correlation between IL-13 and retnla expression.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalPathogens and Disease
Volume67
Issue number3
DOIs
Publication statusPublished - 17 Sept 2013
Externally publishedYes

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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