Restoring cortical connectivity directionality and synchronization is essential to treating disorder of consciousness

Jose León-Carrión, Umberto León-Domínguez, James Halper, Luca Pollonini, George Zouridakis, Maria del Rosario Domínguez-Morales

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The design of neurorehabilitation therapy to treat subjects with altered consciousness provides opportunities and challenges to professionals involved with the care for these severely ill patients. While there is an increased interest in determining methods to restore consciousness in these patients, the process is complex and challenging, due in part to the diverse aetiology of these states of consciousness, and also to the intricate cerebral connectivity involved in their treatment. The present case study examines a patient who showed signs of emergence from the vegetative state after neurorehabilitation using The Combined Method Therapy (CMT). In this case, neurorehabilitation therapy was applied simultaneously with pharmacological treatment, stimulation, and neuroimaging techniques to help adjust drug dosage. The results of this study suggest that this combined approach to treatment promoted connectivity among posterior and anterior cortical regions aiding emergence from the vegetative state. © 2014 Bentham Science Publishers.
Original languageEnglish
Pages (from-to)4268-4274
Number of pages7
JournalCurrent Pharmaceutical Design
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Fingerprint

Consciousness Disorders
Consciousness
Persistent Vegetative State
Therapeutics
Neuroimaging
Pharmacology
Pharmaceutical Preparations
Neurological Rehabilitation

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

León-Carrión, J., León-Domínguez, U., Halper, J., Pollonini, L., Zouridakis, G., & Domínguez-Morales, M. D. R. (2014). Restoring cortical connectivity directionality and synchronization is essential to treating disorder of consciousness. Current Pharmaceutical Design, 4268-4274.
León-Carrión, Jose ; León-Domínguez, Umberto ; Halper, James ; Pollonini, Luca ; Zouridakis, George ; Domínguez-Morales, Maria del Rosario. / Restoring cortical connectivity directionality and synchronization is essential to treating disorder of consciousness. In: Current Pharmaceutical Design. 2014 ; pp. 4268-4274.
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Restoring cortical connectivity directionality and synchronization is essential to treating disorder of consciousness. / León-Carrión, Jose; León-Domínguez, Umberto; Halper, James; Pollonini, Luca; Zouridakis, George; Domínguez-Morales, Maria del Rosario.

In: Current Pharmaceutical Design, 01.01.2014, p. 4268-4274.

Research output: Contribution to journalArticle

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