TY - JOUR
T1 - Relationship of Mitochondrial DNA Haplogroups with Complex Diseases
AU - Urzúa Traslaviña, Carlos G
AU - Moreno Treviño, María Guadalupe
AU - Martínez-Treviño, Denisse Aideé
AU - Barrera-Saldaña, Hugo
AU - León Cachón, Rafael Baltazar Reyes
PY - 2014/12/16
Y1 - 2014/12/16
N2 - Mitochondria are responsible for energy production in unicellular and multicellular eukaryotes. Apart from their major role in metabolism, mitochondria are involved in many other cellular processes. A new paradigm is needed to understand aging, aging-related illnesses, and complex diseases. Because of the long co-evolution of mitochondria with the cells, subtle variations in the function of these organelles could influence many organ systems. Understanding the extent of this influence will shed light on the pathophysiology of some of these diseases. This review will examine the history of mitochondrial DNA research, and explain the role mitochondrial DNA plays in relation to complex diseases and their outcomes, like metabolic diseases, cancer and obesity. Finally, we will explore some of the new paradigms used in this research.
AB - Mitochondria are responsible for energy production in unicellular and multicellular eukaryotes. Apart from their major role in metabolism, mitochondria are involved in many other cellular processes. A new paradigm is needed to understand aging, aging-related illnesses, and complex diseases. Because of the long co-evolution of mitochondria with the cells, subtle variations in the function of these organelles could influence many organ systems. Understanding the extent of this influence will shed light on the pathophysiology of some of these diseases. This review will examine the history of mitochondrial DNA research, and explain the role mitochondrial DNA plays in relation to complex diseases and their outcomes, like metabolic diseases, cancer and obesity. Finally, we will explore some of the new paradigms used in this research.
UR - https://www.mendeley.com/catalogue/e102f110-e968-36d3-bd11-9353cfe64780/
U2 - 10.23937/2378-3648/1410011
DO - 10.23937/2378-3648/1410011
M3 - Article
VL - 1
SP - 1
EP - 5
JO - Journal of Genetics and Genome Research
JF - Journal of Genetics and Genome Research
IS - 2
ER -