TY - JOUR
T1 - Recent Antifungal Pipeline Developments against Candida auris: A Systematic Review
AU - Treviño-Rangel, Rogelio de J.
AU - González, Gloria M.
AU - Montoya, Alexandra M.
AU - Rojas, Olga C.
AU - Elizondo-Zertuche, Mariana
AU - Álvarez-Villalobos, Neri A.
N1 - Funding Information:
This research was funded by the Consejo Nacional de Ciencia y Tecnología (CONACyT– Ciencia Básica y/o Ciencia de Frontera 2022) with the grant no. 319414.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - The alarming spread and impact of multidrug-resistant Candida auris infections alongside the limited therapeutic options have prompted the development of new antifungals. These promising agents are currently in different stages of development, offering novel dosing regimens and mechanisms of action. A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data of in vitro activity and in vivo efficacy of investigational antifungals against C. auris. These included new additions to existing antifungal classes (rezafungin and opelconazole), first-in-class drugs such as ibrexafungerp, manogepix/fosmanogepix, olorofim and tetrazoles (quilseconazole, oteseconazole and VT-1598), as well as other innovative agents like ATI-2307, MGCD290 and VL-2397. From 592 articles retrieved in the primary search, 27 met the eligibility criteria. The most studied agent was manogepix/fosmanogepix (overall MIC
90: 0.03 mg/L), followed by ibrexafungerp (overall MIC
90: 1 mg/L) and rezafungin (overall MIC mode: 0.25 mg/L), while VT-1598 and ATI-2307 were the least explored drugs against C. auris. All these compounds demonstrated significant improvements in survival and reduction in tissue fungal burden on neutropenic animal models of candidemia due to C. auris. Continual efforts towards the discovery of new treatments against this multidrug-resistant fungus are essential.
AB - The alarming spread and impact of multidrug-resistant Candida auris infections alongside the limited therapeutic options have prompted the development of new antifungals. These promising agents are currently in different stages of development, offering novel dosing regimens and mechanisms of action. A systematic search in MEDLINE, EMBASE, Web of Science, and Scopus up to 27 June 2022 was conducted to find relevant articles reporting data of in vitro activity and in vivo efficacy of investigational antifungals against C. auris. These included new additions to existing antifungal classes (rezafungin and opelconazole), first-in-class drugs such as ibrexafungerp, manogepix/fosmanogepix, olorofim and tetrazoles (quilseconazole, oteseconazole and VT-1598), as well as other innovative agents like ATI-2307, MGCD290 and VL-2397. From 592 articles retrieved in the primary search, 27 met the eligibility criteria. The most studied agent was manogepix/fosmanogepix (overall MIC
90: 0.03 mg/L), followed by ibrexafungerp (overall MIC
90: 1 mg/L) and rezafungin (overall MIC mode: 0.25 mg/L), while VT-1598 and ATI-2307 were the least explored drugs against C. auris. All these compounds demonstrated significant improvements in survival and reduction in tissue fungal burden on neutropenic animal models of candidemia due to C. auris. Continual efforts towards the discovery of new treatments against this multidrug-resistant fungus are essential.
UR - https://doi.org/10.3390/jof8111144
UR - http://www.scopus.com/inward/record.url?scp=85141754373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85141754373&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/b3402899-4604-32af-b09d-ca08d21c94d0/
U2 - 10.3390/jof8111144
DO - 10.3390/jof8111144
M3 - Review article
C2 - 36354911
VL - 8
JO - Journal of Fungi
JF - Journal of Fungi
IS - 11
M1 - 1144
ER -