Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis

Florent Duval, Jorge E. Moreno-Cuevas, María Teresa González-Garza, Carlos Rodríguez-Montalvo, Delia Elva Cruz-Vega

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

During chronic liver injury, hepatic stellate cells (HSC) are activated and proliferate, which causes excessive extracellular matrix (ECM) deposition, leading to scar formation and fibrosis. Medicinal plants are gaining popularity as antifibrotic agents, and are often safe, cost-effective, and versatile. This review aims to describe the protective role and mechanisms of medicinal plants in the inhibition of HSC activation and ECM deposition during the pathogenesis of liver fibrosis. A systematic literature review on the anti-fibrotic mechanisms of hepatoprotective plants was performed in PubMed, which yielded articles about twelve relevant plants. Many of these plants act via disruption of the transforming growth factor beta 1 signaling pathway, possibly through reduction in oxidative stress. This reduction could explain the inhibition of HSC activation and reduction in ECM deposition. Medicinal plants could be a source of anti-liver fibrosis compounds.

Original languageEnglish
Article number4
Pages (from-to)27
JournalChinese Medicine (United Kingdom)
Volume9
Issue number12
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Complementary and alternative medicine

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