Protective effect of nitroglycerin ointment and dimethyl sulfoxide on necrosis of skin flaps in rats

Miguel L. De la Parra-Marquez*, Abril Peralta-Enriquez, Victor G. Peña, Sergio Charles-Lozoya

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: To compare the protective effect of nitroglycerin ointment 2% and Dimethylsulfoxide (DMSO) in dorsal flaps of the rat. Methods: A blind, experimental study was conducted in 24 male Wistar rats, with a mean weight of 320 (286-376) grams. Group 1: Control. Petrolatum jelly (Vaseline), n = 8, Group 2: Nitroglycerin (NTG) ointment 2% (Nitro-Bid, Altana Co.) n = 8, and Group 3: DMSO gel 90% (Neogen corp. Lexington KY, 40611), n = 8. Results: A total of 24 rats were operated on in the 6-month period of this study. Using a non-parametric Mann–Whitney U-test analysis, a statistically significant p was obtained between the control group and 2% NTG ointment, both in the area of necrosis and in the healthy area (p = 0.026). In contrast, the comparison between DMSO [CH3) 2SO] and the control group (p = 0.180) and between both study groups, with a p = 0.18, was not significant. Conclusions: Our study concluded that there is a protective effect of 2% NTG ointment for flap survival in relation to the control group (petrolatum). DMSO administered topically did not show a protective effect, compared to the control group.

Translated title of the contributionEfecto protector del unguento de nitroglicerina y el dimetilsulfoxido en la necrosis de colgajos cutáneos en ratas
Original languageEnglish
Pages (from-to)596-600
Number of pages5
JournalCirugia y Cirujanos (English Edition)
Volume91
Issue number5
DOIs
Publication statusPublished - 2023

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Copyright: © 2023 Permanyer.

All Science Journal Classification (ASJC) codes

  • General Medicine

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