Patterns of oral mucosa lesions in patients with epidermolysis bullosa: Comparison and agreement between oral medicine and dermatology

Giulio Fortuna, Francina Lozada-Nur, Annamaria Pollio, Massimo Aria, Rodrigo Cepeda-Valdes, Matt Peter Marinkovich, Anna L. Bruckner, Julio Cesar Salas-Alanís

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The oral mucosa in patients with epidermolysis bullosa (EB) can be affected with different lesions and degrees of severity. However, patterns of oral lesions in distinct types of EB are still unclear. Objectives: The purpose of this study was to determine the frequency and distribution of four types of lesions (erythema, erosion, atrophy, and blister) for each oral site and to calculate the interobserver reliability for each type of lesion in each site. Methods: Ninety-two patients with different EB types were assessed independently by an oral medicine specialist and a dermatologist. The degree of agreement was calculated by the intraclass correlation coefficient (ICC). Results: The most affected oral site was the tongue, with the most frequent lesion being erythema and atrophy [54(58.7%) patients] for the oral medicine specialist and erosion [54(58.7%) patients] for the dermatologist. Patients with recessive dystrophic EB-severe generalized (RDEB-sev gen) showed the highest mean of sites involved by each lesion for both oral medicine and dermatology. The interobserver reliability on the total of lesions was excellent on only 3 sites: lower lip (ICC: 0.89; 95%CI:0.83-0.92), hard palate (ICC:0.85; 95%CI:0.72-0.91), and tongue (ICC:0.89; 95%CI:0.84-0.92), whereas the interobserver reliability calculated for each single oral lesion showed a lower agreement. Conclusion: Total distribution of sites involved by four types of lesions was higher in RDEB-sev gen than in the rest of EB types, with a predominance of erythema followed by erosion. The agreement on the type of lesion was found to be poor-moderate for many oral sites. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Original languageEnglish
Pages (from-to)733-740
Number of pages8
JournalJournal of Oral Pathology and Medicine
DOIs
Publication statusPublished - 1 Nov 2013
Externally publishedYes

Fingerprint

Epidermolysis Bullosa
Oral Medicine
Mouth Mucosa
Dermatology
Erythema
Nuclear Family
Tongue
Atrophy
Epidermolysis Bullosa Dystrophica
Hard Palate
Blister
Lip

Cite this

Fortuna, Giulio ; Lozada-Nur, Francina ; Pollio, Annamaria ; Aria, Massimo ; Cepeda-Valdes, Rodrigo ; Marinkovich, Matt Peter ; Bruckner, Anna L. ; Salas-Alanís, Julio Cesar. / Patterns of oral mucosa lesions in patients with epidermolysis bullosa: Comparison and agreement between oral medicine and dermatology. In: Journal of Oral Pathology and Medicine. 2013 ; pp. 733-740.
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title = "Patterns of oral mucosa lesions in patients with epidermolysis bullosa: Comparison and agreement between oral medicine and dermatology",
abstract = "Background: The oral mucosa in patients with epidermolysis bullosa (EB) can be affected with different lesions and degrees of severity. However, patterns of oral lesions in distinct types of EB are still unclear. Objectives: The purpose of this study was to determine the frequency and distribution of four types of lesions (erythema, erosion, atrophy, and blister) for each oral site and to calculate the interobserver reliability for each type of lesion in each site. Methods: Ninety-two patients with different EB types were assessed independently by an oral medicine specialist and a dermatologist. The degree of agreement was calculated by the intraclass correlation coefficient (ICC). Results: The most affected oral site was the tongue, with the most frequent lesion being erythema and atrophy [54(58.7{\%}) patients] for the oral medicine specialist and erosion [54(58.7{\%}) patients] for the dermatologist. Patients with recessive dystrophic EB-severe generalized (RDEB-sev gen) showed the highest mean of sites involved by each lesion for both oral medicine and dermatology. The interobserver reliability on the total of lesions was excellent on only 3 sites: lower lip (ICC: 0.89; 95{\%}CI:0.83-0.92), hard palate (ICC:0.85; 95{\%}CI:0.72-0.91), and tongue (ICC:0.89; 95{\%}CI:0.84-0.92), whereas the interobserver reliability calculated for each single oral lesion showed a lower agreement. Conclusion: Total distribution of sites involved by four types of lesions was higher in RDEB-sev gen than in the rest of EB types, with a predominance of erythema followed by erosion. The agreement on the type of lesion was found to be poor-moderate for many oral sites. {\circledC} 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
author = "Giulio Fortuna and Francina Lozada-Nur and Annamaria Pollio and Massimo Aria and Rodrigo Cepeda-Valdes and Marinkovich, {Matt Peter} and Bruckner, {Anna L.} and Salas-Alan{\'i}s, {Julio Cesar}",
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Fortuna, G, Lozada-Nur, F, Pollio, A, Aria, M, Cepeda-Valdes, R, Marinkovich, MP, Bruckner, AL & Salas-Alanís, JC 2013, 'Patterns of oral mucosa lesions in patients with epidermolysis bullosa: Comparison and agreement between oral medicine and dermatology', Journal of Oral Pathology and Medicine, pp. 733-740. https://doi.org/10.1111/jop.12094

Patterns of oral mucosa lesions in patients with epidermolysis bullosa: Comparison and agreement between oral medicine and dermatology. / Fortuna, Giulio; Lozada-Nur, Francina; Pollio, Annamaria; Aria, Massimo; Cepeda-Valdes, Rodrigo; Marinkovich, Matt Peter; Bruckner, Anna L.; Salas-Alanís, Julio Cesar.

In: Journal of Oral Pathology and Medicine, 01.11.2013, p. 733-740.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Patterns of oral mucosa lesions in patients with epidermolysis bullosa: Comparison and agreement between oral medicine and dermatology

AU - Fortuna, Giulio

AU - Lozada-Nur, Francina

AU - Pollio, Annamaria

AU - Aria, Massimo

AU - Cepeda-Valdes, Rodrigo

AU - Marinkovich, Matt Peter

AU - Bruckner, Anna L.

AU - Salas-Alanís, Julio Cesar

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Background: The oral mucosa in patients with epidermolysis bullosa (EB) can be affected with different lesions and degrees of severity. However, patterns of oral lesions in distinct types of EB are still unclear. Objectives: The purpose of this study was to determine the frequency and distribution of four types of lesions (erythema, erosion, atrophy, and blister) for each oral site and to calculate the interobserver reliability for each type of lesion in each site. Methods: Ninety-two patients with different EB types were assessed independently by an oral medicine specialist and a dermatologist. The degree of agreement was calculated by the intraclass correlation coefficient (ICC). Results: The most affected oral site was the tongue, with the most frequent lesion being erythema and atrophy [54(58.7%) patients] for the oral medicine specialist and erosion [54(58.7%) patients] for the dermatologist. Patients with recessive dystrophic EB-severe generalized (RDEB-sev gen) showed the highest mean of sites involved by each lesion for both oral medicine and dermatology. The interobserver reliability on the total of lesions was excellent on only 3 sites: lower lip (ICC: 0.89; 95%CI:0.83-0.92), hard palate (ICC:0.85; 95%CI:0.72-0.91), and tongue (ICC:0.89; 95%CI:0.84-0.92), whereas the interobserver reliability calculated for each single oral lesion showed a lower agreement. Conclusion: Total distribution of sites involved by four types of lesions was higher in RDEB-sev gen than in the rest of EB types, with a predominance of erythema followed by erosion. The agreement on the type of lesion was found to be poor-moderate for many oral sites. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

AB - Background: The oral mucosa in patients with epidermolysis bullosa (EB) can be affected with different lesions and degrees of severity. However, patterns of oral lesions in distinct types of EB are still unclear. Objectives: The purpose of this study was to determine the frequency and distribution of four types of lesions (erythema, erosion, atrophy, and blister) for each oral site and to calculate the interobserver reliability for each type of lesion in each site. Methods: Ninety-two patients with different EB types were assessed independently by an oral medicine specialist and a dermatologist. The degree of agreement was calculated by the intraclass correlation coefficient (ICC). Results: The most affected oral site was the tongue, with the most frequent lesion being erythema and atrophy [54(58.7%) patients] for the oral medicine specialist and erosion [54(58.7%) patients] for the dermatologist. Patients with recessive dystrophic EB-severe generalized (RDEB-sev gen) showed the highest mean of sites involved by each lesion for both oral medicine and dermatology. The interobserver reliability on the total of lesions was excellent on only 3 sites: lower lip (ICC: 0.89; 95%CI:0.83-0.92), hard palate (ICC:0.85; 95%CI:0.72-0.91), and tongue (ICC:0.89; 95%CI:0.84-0.92), whereas the interobserver reliability calculated for each single oral lesion showed a lower agreement. Conclusion: Total distribution of sites involved by four types of lesions was higher in RDEB-sev gen than in the rest of EB types, with a predominance of erythema followed by erosion. The agreement on the type of lesion was found to be poor-moderate for many oral sites. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

U2 - 10.1111/jop.12094

DO - 10.1111/jop.12094

M3 - Article

SP - 733

EP - 740

JO - Journal of Oral Pathology and Medicine

JF - Journal of Oral Pathology and Medicine

SN - 0904-2512

ER -