One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico

Jorge Martín Llaca-Díaz, Soraya Mendoza-Olazarán, Adrian Camacho-Ortiz, Samantha Flores, Elvira Garza-González

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

BACKGROUND: Bacterial species from the ESKAPE group (i.e. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) are frequently resistant to antibiotics. The purpose of this study was to monitor the incidence of ESKAPE pathogens at the intensive care unit (ICU) of a tertiary care hospital in Monterrey, Mexico.

METHODS: All clinically relevant organisms isolated from June 2011 to June 2012 were included. Identification and susceptibility testing was performed using panels from Sensititre. Resistance to oxacillin, for S. aureus, and the production of extended spectrum β-lactamases (ESBLs), for K. pneumonia, were determined as defined by the Clinical Laboratory Standards Institute. Also, the presence of vanA and vanB genes was determined in E. faecium vancomycin (VAN)-resistant isolates.

RESULTS: The majority of pathogens (64.5%) isolated in the ICU unit were from the ESKAPE group. The organisms most frequently isolated were A. baumannii (15.8%) and P. aeruginosa (14.3%). A high resistance to carbapenems was detected for A. baumannii (75.3%) while 62% of S. aureus isolates were confirmed to be methicillin resistant. Of the K. pneumoniae isolates, 36.9% were ESBL producers. We detected three E. faecium VAN-resistant isolates, all of which contained the vanA gene.

CONCLUSION: The presence of the ESKAPE group of pathogens is a major problem in the ICU setting. The results of this study support the implementation of special antimicrobial strategies to specifically target these microorganisms.

Original languageEnglish
Pages (from-to)475-81
Number of pages7
JournalChemotherapy
Volume58
Issue number6
DOIs
Publication statusPublished - 2012

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Acinetobacter baumannii
Enterococcus faecium
Mexico
Intensive Care Units
Klebsiella pneumoniae
Vancomycin
Pseudomonas aeruginosa
Staphylococcus aureus
Staphylococcal Pneumonia
Oxacillin
Enterobacter
Methicillin Resistance
Carbapenems
Tertiary Healthcare
Tertiary Care Centers
Genes
Pneumonia
Anti-Bacterial Agents
Incidence

Bibliographical note

Copyright © 2013 S. Karger AG, Basel.

Cite this

Llaca-Díaz, Jorge Martín ; Mendoza-Olazarán, Soraya ; Camacho-Ortiz, Adrian ; Flores, Samantha ; Garza-González, Elvira. / One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico. In: Chemotherapy. 2012 ; Vol. 58, No. 6. pp. 475-81.
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title = "One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico",
abstract = "BACKGROUND: Bacterial species from the ESKAPE group (i.e. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) are frequently resistant to antibiotics. The purpose of this study was to monitor the incidence of ESKAPE pathogens at the intensive care unit (ICU) of a tertiary care hospital in Monterrey, Mexico.METHODS: All clinically relevant organisms isolated from June 2011 to June 2012 were included. Identification and susceptibility testing was performed using panels from Sensititre. Resistance to oxacillin, for S. aureus, and the production of extended spectrum β-lactamases (ESBLs), for K. pneumonia, were determined as defined by the Clinical Laboratory Standards Institute. Also, the presence of vanA and vanB genes was determined in E. faecium vancomycin (VAN)-resistant isolates.RESULTS: The majority of pathogens (64.5{\%}) isolated in the ICU unit were from the ESKAPE group. The organisms most frequently isolated were A. baumannii (15.8{\%}) and P. aeruginosa (14.3{\%}). A high resistance to carbapenems was detected for A. baumannii (75.3{\%}) while 62{\%} of S. aureus isolates were confirmed to be methicillin resistant. Of the K. pneumoniae isolates, 36.9{\%} were ESBL producers. We detected three E. faecium VAN-resistant isolates, all of which contained the vanA gene.CONCLUSION: The presence of the ESKAPE group of pathogens is a major problem in the ICU setting. The results of this study support the implementation of special antimicrobial strategies to specifically target these microorganisms.",
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Llaca-Díaz, JM, Mendoza-Olazarán, S, Camacho-Ortiz, A, Flores, S & Garza-González, E 2012, 'One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico', Chemotherapy, vol. 58, no. 6, pp. 475-81. https://doi.org/10.1159/000346352

One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico. / Llaca-Díaz, Jorge Martín; Mendoza-Olazarán, Soraya; Camacho-Ortiz, Adrian; Flores, Samantha; Garza-González, Elvira.

In: Chemotherapy, Vol. 58, No. 6, 2012, p. 475-81.

Research output: Contribution to journalArticle

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T1 - One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico

AU - Llaca-Díaz, Jorge Martín

AU - Mendoza-Olazarán, Soraya

AU - Camacho-Ortiz, Adrian

AU - Flores, Samantha

AU - Garza-González, Elvira

N1 - Copyright © 2013 S. Karger AG, Basel.

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Bacterial species from the ESKAPE group (i.e. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) are frequently resistant to antibiotics. The purpose of this study was to monitor the incidence of ESKAPE pathogens at the intensive care unit (ICU) of a tertiary care hospital in Monterrey, Mexico.METHODS: All clinically relevant organisms isolated from June 2011 to June 2012 were included. Identification and susceptibility testing was performed using panels from Sensititre. Resistance to oxacillin, for S. aureus, and the production of extended spectrum β-lactamases (ESBLs), for K. pneumonia, were determined as defined by the Clinical Laboratory Standards Institute. Also, the presence of vanA and vanB genes was determined in E. faecium vancomycin (VAN)-resistant isolates.RESULTS: The majority of pathogens (64.5%) isolated in the ICU unit were from the ESKAPE group. The organisms most frequently isolated were A. baumannii (15.8%) and P. aeruginosa (14.3%). A high resistance to carbapenems was detected for A. baumannii (75.3%) while 62% of S. aureus isolates were confirmed to be methicillin resistant. Of the K. pneumoniae isolates, 36.9% were ESBL producers. We detected three E. faecium VAN-resistant isolates, all of which contained the vanA gene.CONCLUSION: The presence of the ESKAPE group of pathogens is a major problem in the ICU setting. The results of this study support the implementation of special antimicrobial strategies to specifically target these microorganisms.

AB - BACKGROUND: Bacterial species from the ESKAPE group (i.e. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) are frequently resistant to antibiotics. The purpose of this study was to monitor the incidence of ESKAPE pathogens at the intensive care unit (ICU) of a tertiary care hospital in Monterrey, Mexico.METHODS: All clinically relevant organisms isolated from June 2011 to June 2012 were included. Identification and susceptibility testing was performed using panels from Sensititre. Resistance to oxacillin, for S. aureus, and the production of extended spectrum β-lactamases (ESBLs), for K. pneumonia, were determined as defined by the Clinical Laboratory Standards Institute. Also, the presence of vanA and vanB genes was determined in E. faecium vancomycin (VAN)-resistant isolates.RESULTS: The majority of pathogens (64.5%) isolated in the ICU unit were from the ESKAPE group. The organisms most frequently isolated were A. baumannii (15.8%) and P. aeruginosa (14.3%). A high resistance to carbapenems was detected for A. baumannii (75.3%) while 62% of S. aureus isolates were confirmed to be methicillin resistant. Of the K. pneumoniae isolates, 36.9% were ESBL producers. We detected three E. faecium VAN-resistant isolates, all of which contained the vanA gene.CONCLUSION: The presence of the ESKAPE group of pathogens is a major problem in the ICU setting. The results of this study support the implementation of special antimicrobial strategies to specifically target these microorganisms.

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DO - 10.1159/000346352

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VL - 58

SP - 475

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JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

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